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1.口腔数智化与个体化诊疗技术湖南省工程研究中心,口腔健康研究湖南省重点实验室,口腔颌面再生王松灵院士专家工作站,中南大学湘雅口腔医学院,长沙 410000
2.江西省万载县人民医院口腔科,宜春 336100
3.中南大学湘雅口腔医院牙周科,长沙 410000
JIANG Jiacan, Email: jiacanjiang@csu.edu.cn, ORCID: 0009-0006-4321-5580
CHEN Jun, Email: chenjun1222@csu.edu.cn, ORCID: 0000-0003-3265-0318
收稿日期:2025-03-26,
网络出版日期:2025-05-29,
蒋嘉灿, 欧阳耀斌, 李文杰, 刘斌杰, 陈珺. 口腔颊黏膜Spitz痣1例[J]. 中南大学学报(医学版), XXXX, XX(XX): 1-4.
JIANG Jiacan, OUYANG Yaobin, LI Wenjie, LIU Binjie, CHEN Jun. Spitz nevus of the buccal mucosa: A case report[J]. Journal of Central South University. Medical Science, XXXX, XX(XX): 1-4.
蒋嘉灿, 欧阳耀斌, 李文杰, 刘斌杰, 陈珺. 口腔颊黏膜Spitz痣1例[J]. 中南大学学报(医学版), XXXX, XX(XX): 1-4. DOI:10.11817/j.issn.1672-7347.2025.250145
JIANG Jiacan, OUYANG Yaobin, LI Wenjie, LIU Binjie, CHEN Jun. Spitz nevus of the buccal mucosa: A case report[J]. Journal of Central South University. Medical Science, XXXX, XX(XX): 1-4. DOI:10.11817/j.issn.1672-7347.2025.250145
Spitz痣是一种罕见的黑素细胞病变,其临床和病理特征类似于恶性黑色素瘤。口腔内黑素细胞病变相对而言较为少见,而颊黏膜处的Spitz痣尤为稀有。经患者允许报告19岁女性患者颊黏膜Spitz痣一例,并进行口腔内Spitz痣的文献复习。
Spitz nevus is a rare melanocytic lesion with clinical and pathological features resembling those of malignant melanoma. Melanocytic lesions within the oral cavity are relatively uncommon
and the occurrence of a Spitz nevus on the buccal mucosa is particularly rare. Under the permission of the patient
a case report of a 19-year-old female patient diagnosed with Spitz nevus on the buccal mucosa was presented. A thorough literature review about oral Spitz nevus was also performed.
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Li CC , Harrist TJ , Noonan VL , et al . Intraoral Spitz nevus: case report and literature review [J ] . Oral Surg Oral Med Oral Pathol Oral Radiol , 2014 , 117 ( 4 ): e320-4 . https://doi.org/10.1016/j.oooo.2013.07.025 https://doi.org/10.1016/j.oooo.2013.07.025 .
Vaccaro M , Romeo U , Romeo C , et al . Spitz nevus: a rare lesion of the oral cavity [J ] . Pediatr Dermatol , 2016 , 33 ( 2 ): e154-5 . https://doi.org/10.1111/pde.12785 https://doi.org/10.1111/pde.12785 .
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Lott JP , Wititsuwannakul J , Lee JJ , et al . Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: the Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008 [J ] . J Am Acad Dermatol , 2014 , 71 ( 6 ): 1077 - 1082 . https://doi.org/10.1016/j.jaad.2014. 08.026 https://doi.org/10.1016/j.jaad.2014.08.026 .
Cheng TW , Ahern MC , Giubellino A . The spectrum of spitz melanocytic lesions: from morphologic diagnosis to molecular classification [J ] . Front Oncol , 2022 , 12 : 889223 . https://doi.org/10.3389/fonc.2022.889223 https://doi.org/10.3389/fonc.2022.889223 .
Metzger AT , Kane AA , Bayliss SJ . Differences in treatment of Spitz nevi and atypical Spitz tumors in pediatric patients among dermatologists and plastic surgeons [J ] . JAMA Dermatol , 2013 , 149 ( 11 ): 1348 - 1350 . https://doi.org/10.1001/jamadermatol.2013.4947 https://doi.org/10.1001/jamadermatol.2013.4947 .
Thomas PS , Babu GS , Anusha RL , et al . Oral malignant melanoma: an unusual presentation [J ] . Gerodontology , 2012 , 29 ( 2 ): e1241-3 . https://doi.org/10.1111/j.1741-2358.2010.00450.x https://doi.org/10.1111/j.1741-2358.2010.00450.x .
Meleti M , Mooi WJ , Casparie MK , et al . Melanocytic nevi of the oral mucosa - no evidence of increased risk for oral malignant melanoma: an analysis of 119 cases [J ] . Oral Oncol , 2007 , 43 ( 10 ): 976 - 981 . https://doi.org/10.1016/j.oraloncology. 2006.11.013 https://doi.org/10.1016/j.oraloncology.2006.11.013 .
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