炎症与肿瘤微环境

牛涛; 周逢海

doi:10.11817/j.issn.1672-7347.2023.230231

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综述 | 更新时间：2024-03-04

炎症与肿瘤微环境
Inflammation and tumor microenvironment
中南大学学报(医学版) 中南大学学报(医学版) 2023年48卷第12期页码：1899-1913
作者机构：

1.甘肃中医药大学第一临床医学院，兰州 730000
2.甘肃省人民医院干部泌尿外科，兰州 730000
作者简介：

牛涛，Email: 379171172@qq.com, ORCID: 0009-0007-9826-7932
周逢海，Email: zhouch21@lzu.edu.cn, ORCID: 0009-0004-5699-3627
基金信息：

甘肃省重点研发项目(21YF5FA016)
DOI：10.11817/j.issn.1672-7347.2023.230231
中图分类号：
CSTR：
收稿日期：2023-06-01，

纸质出版日期：2023-12-28
稿件说明：

牛涛, 周逢海. 炎症与肿瘤微环境[J]. 中南大学学报(医学版), 2023, 48(12): 1899-1913.

NIU Tao, ZHOU Fenghai. Inflammation and tumor microenvironment[J]. Journal of Central South University. Medical Science, 2023, 48(12): 1899-1913.
牛涛, 周逢海. 炎症与肿瘤微环境[J]. 中南大学学报(医学版), 2023, 48(12): 1899-1913. DOI：10.11817/j.issn.1672-7347. 2023.230231

NIU Tao, ZHOU Fenghai. Inflammation and tumor microenvironment[J]. Journal of Central South University. Medical Science, 2023, 48(12): 1899-1913. DOI：10.11817/j.issn. 1672-7347.2023.230231

摘要

炎症与肿瘤之间存在联系。炎症是肿瘤的标志之一，影响肿瘤的进展、向恶性表型的转变以及肿瘤化学治疗药物的疗效，肿瘤微环境通过多种特定因素和信号机制影响肿瘤的生物学特性。炎症与肿瘤微环境之间相互作用，炎症通过诱导免疫抑制来影响肿瘤微环境，急性炎症通过产生抗肿瘤免疫反应来抑制肿瘤。本综述从肿瘤微环境的组分、炎症小体、细胞因子和非编码RNA等方面出发，阐述炎症如何通过影响肿瘤微环境，从而影响肿瘤的进展及治疗。炎症因子在调节炎症反应和免疫应答发挥重要的作用，同时它在肿瘤微环境中通过多种途径影响肿瘤的发展，它可以通过抑制免疫细胞的活性，使肿瘤逃避免疫监视，从而促进肿瘤细胞的增殖和转移。炎症也会引起氧化应激，生成活性氧和活性氮等氧化剂，这些氧化剂会损害核酸、蛋白质和脂质，诱导基因的突变和肿瘤转化。此外，非编码RNA在肿瘤微环境中扮演重要角色，对肿瘤和炎症起调控作用。它们通过多种途径参与调控肿瘤的发生、发展和炎症的过程，也参与调节炎症诱导的肿瘤或肿瘤相关的炎症，以及调节肿瘤微环境、炎症因子和免疫细胞之间的相互作用。因此，更深入地了解炎症与肿瘤微环境之间的相互作用与肿瘤发生、发展之间的联系，可以为肿瘤的治疗提供理论基础和策略。

Abstract

There is a connection between inflammation and cancer. Inflammation is one of the hallmarks of cancer

affecting tumor progression

transition to a malignant phenotype

and the efficacy of tumor chemotherapy. The tumor microenvironment impacts the biological characteristics of tumors through various specific factors and signaling mechanisms. The interaction between inflammation and the tumor microenvironment involves inflammation affecting the tumor microenvironment by inducing immune suppression

while acute inflammation promotes tumor suppression by producing anti-tumor immune responses. This review elaborates on how inflammation affects the tumor microenvironment and thus affects the progression and treatment of tumors

starting from the components of the tumor microenvironment

inflammasomes

cytokines

non-coding RNAs

and other aspects. Inflammatory factors play an important role in regulating inflammatory responses and immune reactions

and they also affect the development of tumors through various pathways in the tumor microenvironment. In addition

non-coding RNAs play an important role in the tumor microenvironment

regulating tumors and inflammation. They are involved in regulating the occurrence

development of tumors

the process of inflammation

as well as regulating inflammation-induced cancer or tumor-related inflammation

and the interaction between the tumor microenvironment

inflammatory factors

and immune cells. Therefore

gaining a deeper understanding of the interaction between inflammation and the tumor microenvironment and its connection to the occurrence and development of cancer can provide a theoretical basis for combating tumors and finding new therapeutic strategies.

关键词

Keywords

references

Hanahan D , Weinberg RA . Hallmarks of cancer: the next generation [J]. Cell , 2011 , 144 ( 5 ): 646 - 674 . https://doi.org/10. 1016/j.cell.2011.02.013 https://doi.org/10.1016/j.cell.2011.02.013 .

Briukhovetska D , Dörr J , Endres S , et al . Interleukins in cancer: from biology to therapy [J]. Nat Rev Cancer , 2021 , 21 ( 8 ): 481 - 499 . https://doi.org/10.1038/s41568-021-00363-z https://doi.org/10.1038/s41568-021-00363-z .

Greten FR , Grivennikov SI . Inflammation and cancer: triggers, mechanisms, and consequences [J]. Immunity , 2019 , 51 ( 1 ): 27 - 41 . https://doi.org/10.1016/j.immuni.2019.06.025 https://doi.org/10.1016/j.immuni.2019.06.025 .

Piotrowski I , Kulcenty K , Suchorska W . Interplay between inflammation and cancer [J]. Rep Pract Oncol Radiother , 2020 , 25 ( 3 ): 422 - 427 . https://doi.org/10.1016/j.rpor.2020.04.004 https://doi.org/10.1016/j.rpor.2020.04.004 .

Onuma K , Kanda Y , Ikeda SS , et al . Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) prevents inflammation-related carcinogenesis in mice, through inhibition of inflammatory cell infiltration [J]. Nutrients , 2015 , 7 ( 12 ): 10237 - 10250 . https://doi.org/10.3390/nu7125531 https://doi.org/10.3390/nu7125531 .

Würtz ET , Hansen J , Røe OD , et al . Asbestos exposure and haematological malignancies: a Danish cohort study [J]. Eur J Epidemiol , 2020 , 35 ( 10 ): 949 - 960 . https://doi.org/10.1007/s10654-020-00609-4 https://doi.org/10.1007/s10654-020-00609-4 .

Vidal AC , Howard LE , Moreira DM , et al . Aspirin, NSAIDs, and risk of prostate cancer: results from the REDUCE study [J]. Clin Cancer Res , 2015 , 21 ( 4 ): 756 - 762 . https://doi.org/10.1158/1078-0432.ccr-14-2235 https://doi.org/10.1158/1078-0432.ccr-14-2235 .

Alvarez-Diaz S , Preaudet A , Samson AL , et al . Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice [J]. Cell Death Differ , 2021 , 28 ( 5 ): 1466 - 1476 . https://doi.org/10.1038/s41418-020-00673-z https://doi.org/10.1038/s41418-020-00673-z .

Muthupalani S , Ge Z , Joy J , et al . Muc5ac null mice are predisposed to spontaneous gastric antro-pyloric hyperplasia and adenomas coupled with attenuated H.pylori -induced corpus mucous metaplasia [J]. Lab Invest , 2019 , 99 ( 12 ): 1887 - 1905 . https://doi.org/10.1038/s41374-019-0293-y https://doi.org/10.1038/s41374-019-0293-y .

万妍 , 刘芳 , 郭闪 , 等 . 非肝硬化乙型肝炎病毒相关肝细胞癌的转录组测序及其对患者生存的影响 [J]. 首都医科大学学报 , 2023 , 44 ( 5 ): 811 - 820 . https://doi.org/10.3969/j.issn.1006-7795.2023.05.016 https://doi.org/10.3969/j.issn.1006-7795.2023.05.016 .

WAN Yan , LIU Fang , GUO Shan , et al . Transcriptome sequencing and survival analysis of noncirrhotic hepatitis B viral (HBV)-related hepatocellular carcinoma [J]. Journal of Capital Medical University , 2023 , 44 ( 5 ): 811 - 820 . https://doi.org/10.3969/j.issn.1006-7795.2023.05.016 https://doi.org/10.3969/j.issn.1006-7795.2023.05.016 .

Lin CC , Chiang JH , Li CI , et al . Independent and joint effect of type 2 diabetes and gastric and hepatobiliary diseases on risk of pancreatic cancer risk: 10-year follow-up of population-based cohort [J]. Br J Cancer , 2014 , 111 ( 11 ): 2180 - 2186 . https://doi.org/10.1038/bjc.2014.525 https://doi.org/10.1038/bjc.2014.525 .

Shi QT , Han S , Liu X , et al . Integrated single-cell and transcriptome sequencing analyses determines a chromatin regulator-based signature for evaluating prognosis in lung adenocarcinoma [J]. Front Oncol , 2022 , 12 : 1031728 . https://doi.org/10.3389/fonc.2022.1031728 https://doi.org/10.3389/fonc.2022.1031728 .

Finn OJ . A believer’s overview of cancer immunosurveillance and immunotherapy [J]. J Immunol , 2018 , 200 ( 2 ): 385 - 391 . https://doi.org/10.4049/jimmunol.1701302 https://doi.org/10.4049/jimmunol.1701302 .

Choi J , Choi W , Joo Y , et al . FGF2-primed 3D spheroids producing IL-8 promote therapeutic angiogenesis in murine hindlimb ischemia [J]. NPJ Regen Med , 2021 , 6 ( 1 ): 48 . https://doi.org/10.1038/s41536-021-00159-7 https://doi.org/10.1038/s41536-021-00159-7 .

Mroue R , Bissell MJ . Three-dimensional cultures of mouse mammary epithelial cells [J]. Methods Mol Biol , 2013 , 945 : 221 - 250 . https://doi.org/10.1007/978-1-62703-125-7_14 https://doi.org/10.1007/978-1-62703-125-7_14 .

Ning RL , Pei YL , Li P , et al . Carbon ion radiotherapy evokes a metabolic reprogramming and individualized response in prostate cancer [J]. Front Public Health , 2021 , 9 : 777160 . https:// doi.org/10.3389/fpubh.2021.777160 https://doi.org/10.3389/fpubh.2021.777160 .

Jones WD , Michener CM , Biscotti C , et al . RNA immune signatures from pan-cancer analysis are prognostic for high-grade serous ovarian cancer and other female cancers [J]. Cancers , 2020 , 12 ( 3 ): 620 . https://doi.org/10.3390/cancers 12030620 https://doi.org/10.3390/cancers12030620 .

Jiang XJ , Wang J , Deng XY , et al . Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape [J]. Mol Cancer , 2019 , 18 ( 1 ): 10 . https://doi.org/10.1186/s12943-018-0928-4 https://doi.org/10.1186/s12943-018-0928-4 .

Qeadan F , Bansal P , Hanson JA , et al . The MK2 pathway is linked to G-CSF, cytokine production and metastasis in gastric cancer: a novel intercorrelation analysis approach [J]. J Transl Med , 2020 , 18 ( 1 ): 137 . https://doi.org/10.1186/s12967-020-02294-z https://doi.org/10.1186/s12967-020-02294-z .

Triner D , Shah YM . Hypoxia-inducible factors: a central link between inflammation and cancer [J]. J Clin Invest , 2016 , 126 ( 10 ): 3689 - 3698 . https://doi.org/10.1172/JCI84430 https://doi.org/10.1172/JCI84430 .

Vadovics M , Ho J , Igaz N , et al . Candida albicans enhances the progression of oral squamous cell carcinoma in vitro and in vivo [J]. mBio , 2021 , 13 ( 1 ): e0314421 . https://doi.org/10.1128/mBio.03144-21 https://doi.org/10.1128/mBio.03144-21 .

Banchereau J , Briere F , Caux C , et al . Immunobiology of dendritic cells [J]. Annu Rev Immunol , 2000 , 18 : 767 - 811 . https:// doi.org/10.1146/annurev.immunol.18.1.767 https://doi.org/10.1146/annurev.immunol.18.1.767 .

Waldman AD , Fritz JM , Lenardo MJ . A guide to cancer immunotherapy: from T cell basic science to clinical practice [J]. Nat Rev Immunol , 2020 , 20 ( 11 ): 651 - 668 . https://doi.org/10.1038/s41577-020-0306-5 https://doi.org/10.1038/s41577-020-0306-5 .

Waldhauer I , Steinle A . NK cells and cancer immunosurveillance [J]. Oncogene , 2008 , 27 ( 45 ): 5932 - 5943 . https://doi.org/10.1038/onc.2008.267 https://doi.org/10.1038/onc.2008.267 .

Zou GY , Zhang XT , Wang L , et al . Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription [J]. Theranostics , 2020 , 10 ( 15 ): 6839 - 6853 . https://doi.org/10.7150/thno.43622 https://doi.org/10.7150/thno.43622 .

Narasimhan A , Shahda S , Kays JK , et al . Identification of potential serum protein biomarkers and pathways for pancreatic cancer Cachexia using an aptamer-based discovery platform [J]. Cancers , 2020 , 12 ( 12 ): 3787 . https://doi.org/10.3390/cancers12123787 https://doi.org/10.3390/cancers12123787 .

Shima T , Shimoda M , Shigenobu T , et al . Infiltration of tumor-associated macrophages is involved in tumor programmed death-ligand 1 expression in early lung adenocarcinoma [J]. Cancer Sci , 2020 , 111 ( 2 ): 727 - 738 . https://doi.org/10.1111/cas.14272 https://doi.org/10.1111/cas.14272 .

Yi HY , Zhang Y , Yang XF , et al . Hepatitis B core antigen impairs the polarization while promoting the production of inflammatory cytokines of M2 macrophages via the TLR2 pathway [J]. Front Immunol , 2020 , 11 : 535 . https://doi.org/10. 3389/fimmu.2020.00535 https://doi.org/10.3389/fimmu.2020.00535 .

Xu WH , Tao JL , Zhu WK , et al . Comprehensive multi-omics identification of interferon-γ response characteristics reveals that RBCK1 regulates the immunosuppressive microenvironment of renal cell carcinoma [J]. Front Immunol , 2021 , 12 : 734646 . https://doi.org/10.3389/fimmu.2021.734646 https://doi.org/10.3389/fimmu.2021.734646 .

Spary LK , Salimu J , Webber JP , et al . Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14 + PD-L1 + phenotype in prostate cancer [J/OL]. Oncoimmunology , 2014 , 3 ( 9 ): e 955331 [ 2023-05-08 ]. https://doi.org/10.4161/21624011.2014.955331 https://doi.org/10.4161/21624011.2014.955331 .

Joshi RS , Kanugula SS , Sudhir S , et al . The role of cancer-associated fibroblasts in tumor progression [J]. Cancers , 2021 , 13 ( 6 ): 1399 . https://doi.org/10.3390/cancers13061399 https://doi.org/10.3390/cancers13061399 .

Ramos-Vega V , Venegas Rojas B , Donoso Torres W . Immunohistochemical analysis of cancer-associated fibroblasts and podoplanin in head and neck cancer [J/OL]. Med Oral Patol Oral Cir Bucal , 2020 , 25 ( 2 ): e268 - e276 [ 2023-05-08 ]. https://doi.org/10.4317/ medoral.23335 https://doi.org/10.4317/medoral.23335 .

Raudenská M , Svobodová M , Gumulec J , et al . The importance of cancer-associated fibroblasts in the pathogenesis of head and neck cancers [J]. Klin Onkol , 2020 , 33 ( 1 ): 39 - 48 . https://doi.org/10.14735/amko202039 https://doi.org/10.14735/amko202039 .

Togo S , Polanska UM , Horimoto Y , et al . Carcinoma-associated fibroblasts are a promising therapeutic target [J]. Cancers , 2013 , 5 ( 1 ): 149 - 169 . https://doi.org/10.3390/cancers5010149 https://doi.org/10.3390/cancers5010149 .

Öhlund D , Handly-Santana A , Biffi G , et al . Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer [J]. J Exp Med , 2017 , 214 ( 3 ): 579 - 596 . https://doi.org/10.1084/jem.20162024 https://doi.org/10.1084/jem.20162024 .

Davidson S , Coles M , Thomas T , et al . Fibroblasts as immune regulators in infection, inflammation and cancer [J]. Nat Rev Immunol , 2021 , 21 ( 11 ): 704 - 717 . https://doi.org/10.1038/s41577-021-00540-z https://doi.org/10.1038/s41577-021-00540-z .

Glyn-Jones S , Palmer AJR , Agricola R , et al . Osteoarthritis [J]. Lancet , 2015 , 386 ( 9991 ): 376 - 387 . https://doi.org/10.1016/S0140-6736(14)60802-3 https://doi.org/10.1016/S0140-6736(14)60802-3 .

Hu F , Zeng W , Liu X . A gene signature of survival prediction for kidney renal cell carcinoma by multi-omic data analysis [J]. Int J Mol Sci , 2019 , 20 ( 22 ): E5720 . 10.3390/ijms20225720 http://dx.doi.org/10.3390/ijms20225720

Li HY , Liu F , Wang XY , et al . Identification of hub lncRNAs along with lncRNA-miRNA-mRNA network for effective diagnosis and prognosis of papillary thyroid cancer [J]. Front Pharmacol , 2021 , 12 : 748867 . https://doi.org/10.3389/fphar.2021.748867 https://doi.org/10.3389/fphar.2021.748867 .

Ray A , Slama ZM , Morford RK , et al . Enhanced directional migration of cancer stem cells in 3D aligned collagen matrices [J]. Biophys J , 2017 , 112 ( 5 ): 1023 - 1036 . https://doi.org/10.1016/j.bpj.2017.01.007 https://doi.org/10.1016/j.bpj.2017.01.007 .

Malanchi I , Santamaria-Martínez A , Susanto E , et al . Interactions between cancer stem cells and their niche govern metastatic colonization [J]. Nature , 2011 , 481 ( 7379 ): 85 - 89 . https://doi.org/10.1038/nature10694 https://doi.org/10.1038/nature10694 .

Wang L , Li H , Shi L , et al . In situ peptide self-assembly on ionic nanochannel for dynamic monitoring of MMPs in extracellular matrix [J]. Biosens Bioelectron , 2022 , 195 : 113671 . https://doi.org/10.1016/j.bios.2021.113671 https://doi.org/10.1016/j.bios.2021.113671 .

Chen XM , Liu YY , Tao BY , et al . NT5E upregulation in head and neck squamous cell carcinoma: a novel biomarker on cancer-associated fibroblasts for predicting immunosuppressive tumor microenvironment [J]. Front Immunol , 2022 , 13 : 975847 . https://doi.org/10.3389/fimmu.2022.975847 https://doi.org/10.3389/fimmu.2022.975847 .

Yuan ZN , Li YP , Zhang SF , et al . Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments [J]. Mol Cancer , 2023 , 22 ( 1 ): 48 . https://doi.org/10.1186/s12943-023-01744-8 https://doi.org/10.1186/s12943-023-01744-8 .

Vanni C , Ognibene M , Finetti F , et al . Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion [J]. Cell Cycle , 2015 , 14 ( 9 ): 1426 - 1437 . https://doi.org/10.1080/15384101.2015.1021516 https://doi.org/10.1080/15384101.2015.1021516 .

Kim H , Banerjee N , Barnes RC , et al . Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo [J]. Mol Carcinog , 2017 , 56 ( 1 ): 197 - 207 . https://doi.org/10.1002/mc.22484 https://doi.org/10.1002/mc.22484 .

Yu SY , Wang SW , Hwang TL , et al . Components from the leaves and twigs of mangrove Lumnitzera racemosa with anti-angiogenic and anti-inflammatory effects [J]. Mar Drugs , 2018 , 16 ( 11 ): 404 . https://doi.org/10.3390/md16110404 https://doi.org/10.3390/md16110404 .

Zhuang WW , Sun HW , Zhang SS , et al . An immunogenomic signature for molecular classification in hepatocellular carcinoma [J]. Mol Ther Nucleic Acids , 2021 , 25 : 105 - 115 . https://doi.org/10.1016/j.omtn.2021.06.024 https://doi.org/10.1016/j.omtn.2021.06.024 .

Kang X , Chen Y , Xin XH , et al . Human amniotic epithelial cells and their derived exosomes protect against cisplatin-induced acute kidney injury without compromising its antitumor activity in mice [J]. Front Cell Dev Biol , 2021 , 9 : 752053 . https://doi.org/10.3389/fcell.2021.752053 https://doi.org/10.3389/fcell.2021.752053 .

Marquevielle J , Robert C , Lagrabette O , et al . Structure of two G-quadruplexes in equilibrium in the KRAS promoter [J]. Nucleic Acids Res , 2020 , 48 ( 16 ): 9336 - 9345 . https://doi.org/10.1093/nar/gkaa387 https://doi.org/10.1093/nar/gkaa387 .

Santibañez JF , Quintanilla M , Bernabeu C . TGF-β/TGF-β receptor system and its role in physiological and pathological conditions [J]. Clin Sci , 2011 , 121 ( 6 ): 233 - 251 . https://doi.org/10.1042/CS20110086 https://doi.org/10.1042/CS20110086 .

Yang L , Huang JH , Ren XB , et al . Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis [J]. Cancer Cell , 2008 , 13 ( 1 ): 23 - 35 . https://doi.org/10.1016/j.ccr.2007.12.004 https://doi.org/10.1016/j.ccr.2007.12.004 .

Massagué J . TGFbeta in cancer [J]. Cell , 2008 , 134 ( 2 ): 215 - 230 . https://doi.org/10.1016/j.cell.2008.07.001 https://doi.org/10.1016/j.cell.2008.07.001 .

Chou YT , Hsieh CH , Chiou SH , et al . CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence [J]. Cell Death Differ , 2012 , 19 ( 12 ): 2015 - 2028 . https://doi.org/10.1038/cdd.2012.91 https://doi.org/10.1038/cdd.2012.91 .

Steinway SN , Zañudo JGT , Ding W , et al . Network modeling of TGFβ signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activation [J]. Cancer Res , 2014 , 74 ( 21 ): 5963 - 5977 . https://doi.org/10.1158/0008-5472.CAN-14-0225 https://doi.org/10.1158/0008-5472.CAN-14-0225 .

Cohen EN , Gao H , Anfossi S , et al . Inflammation mediated metastasis: immune induced epithelial-to-mesenchymal transition in inflammatory breast cancer cells [J/OL]. PLoS One , 2015 , 10 ( 7 ): e 0132710 [ 2023-05-08 ]. https://doi.org/10.1371/journal.pone. 0132710 https://doi.org/10.1371/journal.pone.0132710 .

Ganapathy V , Ge RR , Grazioli A , et al . Targeting the transforming growth factor-beta pathway inhibits human basal-like breast cancer metastasis [J]. Mol Cancer , 2010 , 9 : 122 . https://doi.org/10.1186/1476-4598-9-122 https://doi.org/10.1186/1476-4598-9-122 .

Dalal BI , Keown PA , Greenberg AH . Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma [J]. Am J Pathol , 1993 , 143 ( 2 ): 381 - 389 .

Shi XS , Li RD , Dong XY , et al . IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis [J]. J Transl Med , 2020 , 18 ( 1 ): 55 . https://doi.org/10.1186/s12967-020-02233-y https://doi.org/10.1186/s12967-020-02233-y .

Pierce BL , Ballard-Barbash R , Bernstein L , et al . Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients [J]. J Clin Oncol , 2009 , 27 ( 21 ): 3437 - 3444 . https://doi.org/10.1200/JCO.2008.18.9068 https://doi.org/10.1200/JCO.2008.18.9068 .

Sparano JA , O’Neill A , Graham N , et al . Inflammatory cytokines and distant recurrence in HER2-negative early breast cancer [J]. NPJ Breast Cancer , 2022 , 8 ( 1 ): 16 . https://doi.org/10.1038/s41523-021-00376-9 https://doi.org/10.1038/s41523-021-00376-9 .

Chen QY , Tang QN , Tang LQ , et al . Pretreatment serum amyloid A and C-reactive protein comparing with epstein-barr virus DNA as prognostic indicators in patients with nasopharyngeal carcinoma: a prospective study [J]. Cancer Res Treat , 2018 , 50 ( 3 ): 701 - 711 . https://doi.org/10.4143/crt.2017.180 https://doi.org/10.4143/crt.2017.180 .

Otero R , Solier-López A , Sánchez-López V , et al . Biomarkers of venous thromboembolism recurrence after discontinuation of low molecular weight heparin treatment for cancer-associated thrombosis ( HISPALIS -study) [J]. Cancers , 2022 , 14 ( 11 ): 2771 . https://doi.org/10.3390/cancers14112771 https://doi.org/10.3390/cancers14112771 .

Sproston NR , Ashworth JJ . Role of C-reactive protein at sites of inflammation and infection [J]. Front Immunol , 2018 , 9 : 754 . https://doi.org/10.3389/fimmu.2018.00754 https://doi.org/10.3389/fimmu.2018.00754 .

Li XM , Lv XH , Li ZW , et al . Long noncoding RNA ASLNC07322 functions in VEGF-C expression regulated by Smad4 during colon cancer metastasis [J]. Mol Ther Nucleic Acids , 2019 , 18 : 851 - 862 . https://doi.org/10.1016/j.omtn.2019. 10.012 https://doi.org/10.1016/j.omtn.2019.10.012 .

Das S , Shapiro B , Vucic EA , et al . Tumor cell-derived IL1β promotes desmoplasia and immune suppression in pancreatic cancer [J]. Cancer Res , 2020 , 80 ( 5 ): 1088 - 1101 . https://doi.org/10.1158/0008-5472.CAN-19-2080 https://doi.org/10.1158/0008-5472.CAN-19-2080 .

Tu CE , Hu Y , Zhou PR , et al . Lactate and TGF-β antagonistically regulate inflammasome activation in the tumor microenvironment [J]. J Cell Physiol , 2021 , 236 ( 6 ): 4528 - 4537 . https://doi.org/10.1002/jcp.30169 https://doi.org/10.1002/jcp.30169 .

Ju MY , Bi J , Wei Q , et al . Pan-cancer analysis of NLRP3 inflammasome with potential implications in prognosis and immunotherapy in human cancer [J]. Brief Bioinform , 2021 , 22 ( 4 ): bbaa345 . https://doi.org/10.1093/bib/bbaa345 https://doi.org/10.1093/bib/bbaa345 .

Zheng TY , Wang XD , Yue PP , et al . Prognostic inflammasome-related signature construction in kidney renal clear cell carcinoma based on a pan-cancer landscape [J]. Evid Based Complement Alternat Med , 2020 , 2020 : 3259795 . https://doi.org/10.1155/2020/3259795 https://doi.org/10.1155/2020/3259795 .

Dikalov SI , Dikalova AE , Kirilyuk IA . Coupling of phagocytic NADPH oxidase activity and mitochondrial superoxide production [J]. Front Cardiovasc Med , 2022 , 9 : 942736 . https://doi.org/10.3389/fcvm.2022.942736 https://doi.org/10.3389/fcvm.2022.942736 .

Pereira VS , da Costa Aguiar Alves B , Waisberg J , et al . Detection of COX-2 in liquid biopsy of patients with prostate cancer [J]. J Clin Pathol , 2023 , 76 ( 3 ): 189 - 193 . https://doi.org/10.1136/jclinpath-2021-207755 https://doi.org/10.1136/jclinpath-2021-207755 .

Tsujimoto S , Kishina M , Koda M , et al . Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor Γ [J]. Int J Mol Med , 2016 , 38 ( 3 ): 721 - 728 . https://doi.org/10.3892/ijmm.2016.2674 https://doi.org/10.3892/ijmm.2016.2674 .

Shehzad A , Lee J , Lee YS . Autocrine prostaglandin E₂ signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway [J]. BMB Rep , 2015 , 48 ( 2 ): 109 - 114 . https://doi.org/10.5483/bmbrep.2015.48.2.081 https://doi.org/10.5483/bmbrep.2015.48.2.081 .

Goodwin DC , Landino LM , Marnett LJ . Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis [J]. FASEB J , 1999 , 13 ( 10 ): 1121 - 1136 . https://doi.org/10.1096/fasebj.13.10.1121 https://doi.org/10.1096/fasebj.13.10.1121 .

Breyer RM , Bagdassarian CK , Myers SA , et al . Prostanoid receptors: subtypes and signaling [J]. Annu Rev Pharmacol Toxicol , 2001 , 41 : 661 - 690 . https://doi.org/10.1146/annurev.pharmtox.41.1.661 https://doi.org/10.1146/annurev.pharmtox.41.1.661 .

Chang SH , Liu CH , Wu MT , et al . Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E 2 receptor [J]. Prostaglandins Other Lipid Mediat , 2005 , 76 ( 1/2/3/4 ): 48 - 58 . https://doi.org/10.1016/j.prostaglandins.2004.12.001 https://doi.org/10.1016/j.prostaglandins.2004.12.001 .

Wang S , Yu L , Sun GF , et al . Danhong injection protects hemorrhagic brain by increasing Peroxiredoxin 1 in aged rats [J]. Front Pharmacol , 2020 , 11 : 346 . https://doi.org/10.3389/fphar.2020.00346 https://doi.org/10.3389/fphar.2020.00346 .

Xiao L , Mochizuki M , Nakahara T , et al . Hydrogen-generating silica material prevents UVA-ray-induced cellular oxidative stress, cell death, collagen loss and melanogenesis in human cells and 3D skin equivalents [J]. Antioxidants , 2021 , 10 ( 1 ): 76 . https://doi.org/10.3390/antiox10010076 https://doi.org/10.3390/antiox10010076 .

Nguyen DT , Wu BJ , Long HA , et al . Variable spontaneous mutation and loss of heterozygosity among heterozygous genomes in yeast [J]. Mol Biol Evol , 2020 , 37 ( 11 ): 3118 - 3130 . https://doi.org/10.1093/molbev/msaa150 https://doi.org/10.1093/molbev/msaa150 .

Cao J , An WW , Reeves AG , et al . A chemiluminescent probe for cellular peroxynitrite using a self-immolative oxidative decarbonylation reaction [J]. Chem Sci , 2018 , 9 ( 9 ): 2552 - 2558 . https://doi.org/10.1039/c7sc05087a https://doi.org/10.1039/c7sc05087a .

Li PC , Ramm GA , MacDonald GA . Value of the 8-oxodG/dG ratio in chronic liver inflammation of patients with hepatocellular carcinoma [J]. Redox Biol , 2016 , 8 : 259 - 270 . https://doi.org/10.1016/j.redox.2016.02.003 https://doi.org/10.1016/j.redox.2016.02.003 .

马刚 , 张汝鹏 , 梁寒 . 幽门螺杆菌与胃癌相关的研究进展 [J]. 中国肿瘤临床 , 2023 , 50 ( 1 ): 44 - 48 . https://doi.org/10.12354/j.issn.1000-8179.2023.20220623 https://doi.org/10.12354/j.issn.1000-8179.2023.20220623 .

MA Gang , ZHANG Rupeng , LIANG Han . Research progress of Helicobacter pylori infection and gastric cancer [J]. Chinese Journal of Clinical Oncology , 2023 , 50 ( 1 ): 44 - 48 . https://doi.org/10.12354/j.issn.1000-8179.2023.20220623 https://doi.org/10.12354/j.issn.1000-8179.2023.20220623 .

Yu CX , Sun S . An emerging role for circular RNAs in osteoarthritis [J]. Yonsei Med J , 2018 , 59 ( 3 ): 349 - 355 . https://doi.org/10.3349/ymj.2018.59.3.349 https://doi.org/10.3349/ymj.2018.59.3.349 .

Qadir J , Li FY , Yang BB . Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer [J]. Theranostics , 2022 , 12 ( 9 ): 4269 - 4287 . https://doi.org/10.7150/thno.71708 https://doi.org/10.7150/thno.71708 .

Bian Q , Chen B , Weng B , et al . circBTBD7 promotes immature porcine Sertoli cell growth through modulating miR-24-3p/ MAPK7 axis to inactivate p38 MAPK signaling pathway [J]. Int J Mol Sci , 2021 , 22 ( 17 ): 9385 . https://doi.org/10.3390/ijms22179385 https://doi.org/10.3390/ijms22179385 .

Kurtović M , Piteša N , Bartoniček N , et al . RNA-seq and ChIP-seq identification of unique and overlapping targets of GLI transcription factors in melanoma cell lines [J]. Cancers , 2022 , 14 ( 18 ): 4540 . https://doi.org/10.3390/cancers14184540 https://doi.org/10.3390/cancers14184540 .

Wu FL , Yang J , Liu JJ , et al . Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer [J]. Signal Transduct Target Ther , 2021 , 6 ( 1 ): 218 . https://doi.org/10.1038/s41392-021-00641-0 https://doi.org/10.1038/s41392-021-00641-0 .

Wang YF , Li MY , Tang YF , et al . Circular RNA circEIF3I promotes papillary thyroid carcinoma progression through competitively binding to miR-149 and upregulating KIF2A expression [J]. Am J Cancer Res , 2020 , 10 ( 4 ): 1130 - 1139 .

Jiang R , Li H , Yang JM , et al . CircRNA profiling reveals an abundant circFUT10 that promotes adipocyte proliferation and inhibits adipocyte differentiation via sponging let-7 [J]. Mol Ther Nucleic Acids , 2020 , 20 : 491 - 501 . https://doi.org/10.1016/j.omtn.2020.03.011 https://doi.org/10.1016/j.omtn.2020.03.011 .

Xue C , Li GL , Lu J , et al . Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression [J]. Signal Transduct Target Ther , 2021 , 6 ( 1 ): 400 . https://doi.org/10.1038/s41392-021-00788-w https://doi.org/10.1038/s41392-021-00788-w .

Dou YC , Kawaler EA , Cui Zhou D , et al . Proteogenomic characterization of endometrial carcinoma [J/OL]. Cell , 2020 , 180 ( 4 ): 729 - 748 .e 26 e26[ 2023-05-08 ]. https://doi.org/10.1016/j.cell.2020.01.026 https://doi.org/10.1016/j.cell.2020.01.026 .

Akira S , Maeda K . Control of RNA stability in immunity [J]. Annu Rev Immunol , 2021 , 39 : 481 - 509 . https://doi.org/10. 1146/annurev-immunol-101819-075147 https://doi.org/10.1146/annurev-immunol-101819-075147 .

Schultz CW , Preet R , Dhir T , et al . Understanding and targeting the disease-related RNA binding protein human antigen R (HuR) [J/OL]. Wiley Interdiscip Rev RNA , 2020 , 11 ( 3 ): e 1581 [ 2023-05-08 ]. https://doi.org/10.1002/wrna.1581 https://doi.org/10.1002/wrna.1581 .

Liu RP , Wu KY , Li YJ , et al . Human antigen R: a potential therapeutic target for liver diseases [J]. Pharmacol Res , 2020 , 155 : 104684 . https://doi.org/10.1016/j.phrs.2020.104684 https://doi.org/10.1016/j.phrs.2020.104684 .

Wan DW , Wang ST , Xu ZH , et al . PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer [J/OL]. Clin Transl Med , 2022 , 12 ( 2 ): e 683 [ 2023-05-08 ]. https://doi.org/10.1002/ctm2.683 https://doi.org/10.1002/ctm2.683 .

Liu J , Chen S , Wang W , et al . Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways [J]. Cancer Lett , 2016 , 379 ( 1 ): 49 - 59 . https://doi.org/10.1016/j.canlet.2016. 05.022 https://doi.org/10.1016/j.canlet.2016.05.022 .

Liu T , Zhang LY , Joo D , et al . NF-κB signaling in inflammation [J]. Signal Transduct Target Ther , 2017 , 2 : 17023 . https://doi.org/10.1038/sigtrans.2017.23 https://doi.org/10.1038/sigtrans.2017.23 .

Fu XW , Sun G , Tu SJ , et al . Hsa_circ_0046523 mediates an immunosuppressive tumor microenvironment by regulating miR-148a-3p/PD-L1 axis in pancreatic cancer [J]. Front Oncol , 2022 , 12 : 877376 . https://doi.org/10.3389/fonc.2022.877376 https://doi.org/10.3389/fonc.2022.877376 .

Shi L , Yan PJ , Liang YL , et al . Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma [J/OL]. Cell Death Dis , 2017 , 8 ( 11 ): e 3171 [ 2023-05-08 ]. https://doi.org/10.1038/cddis.2017.556 https://doi.org/10.1038/cddis.2017.556 .

Chen J , Wang F , Xu H , et al . Long non-coding RNA SNHG1 regulates the Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways via EZH2 to affect the proliferation, apoptosis, and autophagy of prostate cancer cell [J]. Front Oncol , 2020 , 10 : 552907 . https://doi.org/10.3389/fonc.2020.552907 https://doi.org/10.3389/fonc.2020.552907 .

Wang ZH , Yang B , Zhang M , et al . lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer [J]. Cancer Cell , 2018 , 33 ( 4 ): 706 - 720.e9 . https://doi.org/10.1016/j.ccell.2018.03.006 https://doi.org/10.1016/j.ccell.2018.03.006 .

侯艳娇 . LncRNA EPIC1激活Ang2/Tie2信号通路促进非小细胞肺癌血管生成的研究 [D]. 济南 : 山东大学 , 2021 .

HOU Yanjiao . Study on activation of Ang2/Tie2 signaling pathway by LncRNA EPIC1 to promote angiogenesis in non-small cell lung cancer [D]. Jinan : Shandong University , 2021 .

唐智国 , 魏灿 , 邰胜 . 长链非编码RNA-EPIC1在前列腺癌中的表达及其临床意义 [J]. 安徽医学 , 2021 , 42 ( 7 ): 709 - 713 . https://doi.org/10.3969/j.issn.1000-0399.2021. 07.001 https://doi.org/10.3969/j.issn.1000-0399.2021.07.001 .

TANG Zhiguo , WEI Can , TAI Sheng . Relationship between long non-coding RNA-EPIC1 with lymph node metastasis and prognosis in prostate cancer [J]. Anhui Medical Journal , 2021 , 42 ( 7 ): 709 - 713 . https://doi.org/10.3969/j.issn.1000-0399.2021. 07.001 https://doi.org/10.3969/j.issn.1000-0399.2021.07.001 .

Nie HX , Zhang L , He T , et al . lncRNA-XLOC 012370 promotes the development of pancreatic cancer and inactivates the NF-κB pathway through miR-140-5p [J]. Front Oncol , 2020 , 10 : 620550 . https://doi.org/10.3389/fonc.2020.620550 https://doi.org/10.3389/fonc.2020.620550 .

Zhang BS , Lin JW , Zhang JQ , et al . Integrated chromatin accessibility and transcriptome landscapes of 5-fluorouracil-resistant colon cancer cells [J]. Front Cell Dev Biol , 2022 , 10 : 838332 . https://doi.org/10.3389/fcell.2022.838332 https://doi.org/10.3389/fcell.2022.838332 .

Matouk IJ , Raveh E , Abu-lail R , et al . Oncofetal H19 RNA promotes tumor metastasis [J]. Biochim Biophys Acta , 2014 , 1843 ( 7 ): 1414 - 1426 . https://doi.org/10.1016/j.bbamcr.2014.03.023 https://doi.org/10.1016/j.bbamcr.2014.03.023 .

Raveh E , Matouk IJ , Gilon M , et al . The H19 Long non-coding RNA in cancer initiation, progression and metastasis-a proposed unifying theory [J]. Mol Cancer , 2015 , 14 : 184 . https://doi.org/10.1186/s12943-015-0458-2 https://doi.org/10.1186/s12943-015-0458-2 .

Lu YQ , Hu ZY , Mangala LS , et al . MYC targeted long noncoding RNA DANCR promotes cancer in part by reducing p21 levels [J]. Cancer Res , 2018 , 78 ( 1 ): 64 - 74 . https://doi.org/10.1158/0008-5472.CAN-17-0815 https://doi.org/10.1158/0008-5472.CAN-17-0815 .

Zhang KJ , Tan XL , Guo L . The long non-coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2-dependent suppression of SOCS3 transcription [J]. Mol Oncol , 2020 , 14 ( 2 ): 309 - 328 . https://doi.org/10.1002/1878-0261.12622 https://doi.org/10.1002/1878-0261.12622 .

Zhou H , Wang FB , Chen H , et al . Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer [J]. Aging , 2016 , 8 ( 9 ): 2023 - 2038 . https://doi.org/10.18632/aging.101048 https://doi.org/10.18632/aging.101048 .

Tian FM , Meng FQ , Wang XB . Overexpression of long-noncoding RNA ZFAS1 decreases survival in human NSCLC patients [J]. Eur Rev Med Pharmacol Sci , 2016 , 20 ( 24 ): 5126 - 5131 .

Li T , Xie JJ , Shen C , et al . Amplification of long noncoding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma [J]. Cancer Res , 2015 , 75 ( 15 ): 3181 - 3191 . https://doi.org/10.1158/0008-5472.CAN-14-3721 https://doi.org/10.1158/0008-5472.CAN-14-3721 .

He AB , He SM , Li XS , et al . ZFAS1: a novel vital oncogenic lncRNA in multiple human cancers [J]. Cell Prolif , 2019 , 52 ( 1 ): e12513 . https://doi.org/10.1111/cpr.12513 https://doi.org/10.1111/cpr.12513 .

Geng Z , Dong BZ , Lv WS , et al . LncRNA ZFAS1 regulates the proliferation, oxidative stress, fibrosis, and inflammation of high glucose-induced human mesangial cells via the miR-588/ROCK1 axis [J]. Diabetol Metab Syndr , 2022 , 14 ( 1 ): 21 . https://doi.org/10.1186/s13098-022-00791-3 https://doi.org/10.1186/s13098-022-00791-3 .

徐红艳 , 楚晓飞 , 葛茂功 , 等 . MiR497HG靶向miR-588调控肺癌细胞增殖、迁移侵袭和凋亡的机制研究 [J]. 临床肺科杂志 , 2020 , 25 ( 3 ): 393 - 398 . https://doi.org/10.3969/j.issn.1009-6663.2020.03.017 https://doi.org/10.3969/j.issn.1009-6663.2020.03.017

XU Hongyan , CHU Xiaofei , GE Maogong , et al . Mechanism of MiR497HG regulating cell proliferation, migration, invasion and apoptosis of lung cancer cells by targeting miR-588 [J]. Journal of Clinical Pulmonary Medicine , 2020 , 25 ( 3 ): 393 - 398 . https://doi.org/10.3969/j.issn.1009-6663.2020.03.017 https://doi.org/10.3969/j.issn.1009-6663.2020.03.017 .

Yu M , Zhang X , Li H , et al . MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer [J]. Med Sci Monit , 2017 , 23 : 5690 - 5696 . https://doi.org/10.12659/msm.905126 https://doi.org/10.12659/msm.905126 .

Fattahi F , Kiani J , Khosravi M , et al . Enrichment of up-regulated and down-regulated gene clusters using gene ontology, miRNAs and lncRNAs in colorectal cancer [J]. Comb Chem High Throughput Screen , 2019 , 22 ( 8 ): 534 - 545 . https://doi.org/10.2174/1386207321666191010114149 https://doi.org/10.2174/1386207321666191010114149 .

Han S , Chen XR , Huang L . The tumor therapeutic potential of long non-coding RNA delivery and targeting [J]. Acta Pharm Sin B , 2023 , 13 ( 4 ): 1371 - 1382 . https://doi.org/10.1016/j.apsb. 2022.12.005 https://doi.org/10.1016/j.apsb.2022.12.005 .

Merritt WM , Lin YG , Han LY , et al . Dicer, Drosha, and outcomes in patients with ovarian cancer [J]. N Engl J Med , 2008 , 359 ( 25 ): 2641 - 2650 . https://doi.org/10.1056/NEJMoa0803785 https://doi.org/10.1056/NEJMoa0803785 .

Rupaimoole R , Wu SY , Pradeep S , et al . Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression [J]. Nat Commun , 2014 , 5 : 5202 . https://doi.org/10. 1038/ncomms6202 https://doi.org/10.1038/ncomms6202 .

Ma L , Teruya-Feldstein J , Weinberg RA . Tumour invasion and metastasis initiated by microRNA-10b in breast cancer [J]. Nature , 2007 , 449 ( 7163 ): 682 - 688 . https://doi.org/10.1038/nature06174 https://doi.org/10.1038/nature06174 .

Medina PP , Nolde M , Slack FJ . OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma [J]. Nature , 2010 , 467 ( 7311 ): 86 - 90 . https://doi.org/10.1038/nature09284 https://doi.org/10.1038/nature09284 .

Ma ZJ , Wei K , Yang FM , et al . Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer [J]. Cell Death Dis , 2021 , 12 ( 9 ): 840 . https://doi.org/10.1038/s41419-021-04037-4 https://doi.org/10.1038/s41419-021-04037-4 .

Taganov KD , Boldin MP , Chang KJ , et al . NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [J]. Proc Natl Acad Sci USA , 2006 , 103 ( 33 ): 12481 - 12486 . https://doi.org/10.1073/pnas.0605298103 https://doi.org/10.1073/pnas.0605298103 .

Bhaumik D , Scott GK , Schokrpur S , et al . Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells [J]. Oncogene , 2008 , 27 ( 42 ): 5643 - 5647 . https://doi.org/10.1038/onc.2008.171 https://doi.org/10.1038/onc.2008.171 .

Lin SL , Chiang A , Chang D , et al . Loss of mir-146a function in hormone-refractory prostate cancer [J]. RNA , 2008 , 14 ( 3 ): 417 - 424 . https://doi.org/10.1261/rna.874808 https://doi.org/10.1261/rna.874808 .

Li YW , Vandenboom TG , Wang ZW , et al . MiR-146a suppresses invasion of pancreatic cancer cells [J]. Cancer Res , 2010 , 70 ( 4 ): 1486 - 1495 . https://doi.org/10.1158/0008-5472.CAN-09-2792 https://doi.org/10.1158/0008-5472.CAN-09-2792 .

Zhang Z , Zhang Y , Sun XX , et al . MicroRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma [J]. Mol Cancer , 2015 , 14 : 5 . https://doi.org/10.1186/1476-4598-14-5 https://doi.org/10.1186/1476-4598-14-5 .

Shinohara H , Kuranaga Y , Kumazaki M , et al . Regulated polarization of tumor-associated macrophages by miR-145 via colorectal cancer-derived extracellular vesicles [J]. J Immunol , 2017 , 199 ( 4 ): 1505 - 1515 . https://doi.org/10.4049/jimmunol.1700167 https://doi.org/10.4049/jimmunol.1700167 .

Meng FD , Wei JC , Qu K , et al . FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma [J]. World J Gastroenterol , 2015 , 21 ( 1 ): 196 - 213 . https://doi.org/10.3748/wjg.v21.i1.196 https://doi.org/10.3748/wjg.v21.i1.196 .

Hsieh CH , Tai SK , Yang MH . Snail-overexpressing cancer cells promote M2-like polarization of tumor-associated macrophages by delivering miR-21-abundant exosomes [J]. Neoplasia , 2018 , 20 ( 8 ): 775 - 788 . https://doi.org/10.1016/j.neo.2018.06.004 https://doi.org/10.1016/j.neo.2018.06.004 .

Cooks T , Pateras IS , Jenkins LM , et al . Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 [J]. Nat Commun , 2018 , 9 ( 1 ): 771 . https://doi.org/10.1038/s41467-018-03224-w https://doi.org/10.1038/s41467-018-03224-w .

李雨薇 , 王裕民 , 张雪莹 , 等 . 长链非编码RNA HOTAIR在恶性肿瘤中的研究进展 [J]. 生物化学与生物物理进展 , 2015 , 42 ( 3 ): 228 - 235 . https://doi.org/10.16476/j.pibb.2014.0230 https://doi.org/10.16476/j.pibb.2014.0230 .

LI Yuwei , WANG Yumin , ZHANG Xueying , et al . Progress of long noncoding RNA HOTAIR in human cancer [J]. Progress in Biochemistry and Biophysics , 2015 , 42 ( 3 ): 228 - 235 . https://doi.org/10.16476/j.pibb.2014.0230 https://doi.org/10.16476/j.pibb.2014.0230 .

Huang PJ , Chiu CC , Hsiao MH , et al . Potential of antiviral drug oseltamivir for the treatment of liver cancer [J]. Int J Oncol , 2021 , 59 ( 6 ): 109 . https://doi.org/10.3892/ijo.2021.5289 https://doi.org/10.3892/ijo.2021.5289 .

Kleeff J , Korc M , Apte M , et al . Pancreatic cancer [J]. Nat Rev Dis Primers , 2016 , 2 : 16022 . https://doi.org/10.1038/nrdp. 2016.22 https://doi.org/10.1038/nrdp.2016.22 .

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