干细胞样记忆T细胞在自身免疫性疾病中的作用

刘祉辰; 焦晴晴; 解欢霞; 刘济生

doi:10.11817/j.issn.1672-7347.2023.230051

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综述 | 更新时间：2023-09-19

干细胞样记忆T细胞在自身免疫性疾病中的作用
Role of stem cell-like memory T cells in autoimmune diseases
中南大学学报(医学版) 中南大学学报(医学版) 2023年48卷第7期页码：1098-1104
作者机构：

1.苏州大学附属第一医院耳鼻咽喉科，江苏苏州 215006
2.苏州大学附属第一医院皮肤性病科，江苏苏州 215006
作者简介：

刘祉辰，Email: lllzc1230@163.com, ORCID: 0000-0002-6574-4719
刘济生，Email: sdfyyljs@sina.com, ORCID: 0000-0003-4611-8023
基金信息：

国家自然科学基金(82073434)
DOI：10.11817/j.issn.1672-7347.2023.230051
中图分类号：
CSTR：

刘祉辰, 焦晴晴, 解欢霞, 等. 干细胞样记忆T细胞在自身免疫性疾病中的作用[J]. 中南大学学报(医学版), 2023,48(7):1098-1104.

LIU Zhichen, JIAO Qingqing, XIE Huanxia, et al. Role of stem cell-like memory T cells in autoimmune diseases[J]. Journal of Central South University. Medical Science, 2023,48(7):1098-1104.
刘祉辰, 焦晴晴, 解欢霞, 等. 干细胞样记忆T细胞在自身免疫性疾病中的作用[J]. 中南大学学报(医学版), 2023,48(7):1098-1104. DOI： 10.11817/j.issn.1672-7347.2023.230051.

LIU Zhichen, JIAO Qingqing, XIE Huanxia, et al. Role of stem cell-like memory T cells in autoimmune diseases[J]. Journal of Central South University. Medical Science, 2023,48(7):1098-1104. DOI： 10.11817/j.issn.1672-7347.2023.230051.

摘要

干细胞样记忆T(stem cell-like memory T，T,SCM,)细胞是一种长寿的、具有持续自我更新能力及重建记忆、效应T细胞亚群的多分化潜能的记忆T细胞亚群，是记忆T细胞系统中的最小分化细胞，具有类似干细胞的生物学特征，对于维持功能性免疫至关重要。由于T,SCM,细胞强大的免疫重建功能，它在人类的许多病理和生理过程中发挥着核心作用，在多种自身免疫性疾病的发生及发展中起重要作用。T,SCM,细胞在自身免疫性疾病中的独特作用可能使其成为治疗多种自身免疫性疾病的潜在靶点，可在相关疾病治疗中进行有效的免疫功能重建。

Abstract

Stem cell-like memory T (T,SCM,) cell is a memory T cell subset with characteristics of long life span, consistent self-renewing, and the multipotent capacity to reconstitute the memory and effector T cell subsets. T,SCM, cell is the least differentiated cell in the memory T lymphocyte system, endowed with the stem cell-like ability, and it is essential for maintaining functional immunity. In addition, owing to its robust potential for immune reconstitution, it is central player in many physiological and pathological human processes. T,SCM, cell plays an important role in the occurrence and development of various autoimmune diseases. The specific role of T,SCM, cell in autoimmune diseases may make it a potential target for the treatment of multiple autoimmune diseases, driving effective immune reconstitution in therapy.

关键词

干细胞样记忆T细胞自身免疫性疾病细胞分化免疫治疗

Keywords

stem cell-like memory T cellautoimmune diseasescell differentiationimmunotherapy

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