cGAS-STING通路在代谢性心血管疾病中的作用

丁慧晴; 周玉莹; 印旨意; 台适

doi:10.11817/j.issn.1672-7347.2023.230028

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综述 | 更新时间：2023-09-19

cGAS-STING通路在代谢性心血管疾病中的作用
Role of cGAS-STING signaling pathway in cardiometabolic diseases
中南大学学报(医学版) 中南大学学报(医学版) 2023年48卷第7期页码：1086-1097
作者机构：

1.中南大学湘雅二医院心血管内科,长沙 410011
2.湘潭市中心医院心血管内科,湖南湘潭 411199
3.中南大学湘雅二医院输血科,长沙 410011
作者简介：

丁慧晴，Email: dhq0827@163.com, ORCID: 0009-0004-8166-8981
台适，Email: taishi2017@csu.edu.cn, ORCID: 0000-0002-5802-2910
基金信息：

国家自然科学基金(82271601;81801394)
DOI：10.11817/j.issn.1672-7347.2023.230028
中图分类号：
CSTR：
纸质出版日期： 2023-07-28 ，

收稿日期： 2023-01-20 ，

丁慧晴, 周玉莹, 印旨意, 台适. cGAS-STING通路在代谢性心血管疾病中的作用[J]. 中南大学学报(医学版), 2023, 48(7): 1086-1097.

DING Huiqing, ZHOU Yuying, YIN Zhiyi, TAI Shi. Role of cGAS-STING signaling pathway in cardiometabolic diseases[J]. Journal of Central South University. Medical Science, 2023, 48(7): 1086-1097.
丁慧晴, 周玉莹, 印旨意, 台适. cGAS-STING通路在代谢性心血管疾病中的作用[J]. 中南大学学报(医学版), 2023, 48(7): 1086-1097. DOI：10.11817/j.issn.1672-7347.2023.230028

DING Huiqing, ZHOU Yuying, YIN Zhiyi, TAI Shi. Role of cGAS-STING signaling pathway in cardiometabolic diseases[J]. Journal of Central South University. Medical Science, 2023, 48(7): 1086-1097. DOI：10.11817/j.issn.1672-7347.2023.230028

摘要

代谢性心血管疾病是糖脂代谢紊乱与心血管功能损害之间存在因果关联的临床常见综合征，但具体发病机制不清。环磷酸鸟苷-腺苷酸合成酶(cyclic guanosine monophosphate-adenosine monophosphate synthase，cGAS)-干扰素基因刺激因子(stimulator of interferon gene，STING)信号通路通过识别双链DNA激活固有免疫。代谢性危险因素引起线粒体DNA、核DNA在细胞质中的浓度上升以及内质网应激，驱动cGAS-STING通路激活，从而触发反复无菌性免疫炎症反应、细胞自噬水平上调、细胞衰老及细胞凋亡，最终表现为心血管不良结局的发生与发展。因此，靶向干预cGAS-STING信号通路或将成为治疗代谢性心血管疾病的崭新方式。

Abstract

Cardiometabolic disease is a common clinical syndrome with exact causal relationship between the aberrant of glucose/lipid metabolism and cardiovascular disfunction

but its pathogenesis is unclear. Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway regulates the activation of innate immunity by sensing intracellular double stranded DNA. Metabolic risk factors drive the activation of cGAS-STING pathway through mitochondrial DNA

nuclear DNA and endoplasmic reticulum stress. In addition

the activation of the cGAS-STING pathway triggers chronic sterile inflammation

excessive activation of autophagy

senescence and apoptosis in related cells of cardiovascular system. These changes induced by cGAS-STING pathway might be implicated in the onset and deterioration of cardiometabolic disease. Therefore

the targeting intervention of cGAS-STING signaling pathway may emerge as a novel treatment for cardiometabolic disease.

关键词

腺苷酸合成酶-干扰素基因刺激因子信号通路自噬衰老代谢性心血管疾病

Keywords

cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene signaling pathwayautophagysenescencecardiometabolic disease

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