干细胞样记忆性T细胞在自身免疫性疾病中的研究进展

刘祉辰; 焦晴晴; 解欢霞; 刘济生

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更新时间：2023-06-16

干细胞样记忆性T细胞在自身免疫性疾病中的研究进展
Research progress of stem cell-like memory T cells in autoimmune diseases
中南大学学报(医学版) 中南大学学报(医学版) 2023年页码：1-7
作者机构：

1.苏州大学附属第一医院耳鼻咽喉科，江苏苏州 215006
2.苏州大学附属第一医院皮肤性病科，江苏苏州 215006
作者简介：

刘祉辰，Email: lllzc1230@163.com, ORCID:
刘济生，Email: sdfyyljs@sina.com
基金信息：

国家自然科学基金(82073434)
DOI：
中图分类号：
CSTR：
网络出版日期： 2023-06-16 ，

收稿日期： 2023-02-16 ，

刘祉辰, 焦晴晴, 解欢霞, 刘济生. 干细胞样记忆性T细胞在自身免疫性疾病中的研究进展[J]. 中南大学学报(医学版), XXXX, XX(XX): 1-7.

LIU Zhichen, JIAO Qingqing, XIE Huanxia, LIU Jisheng. Research progress of stem cell-like memory T cells in autoimmune diseases[J]. Journal of Central South University. Medical Science, XXXX, XX(XX): 1-7.
刘祉辰, 焦晴晴, 解欢霞, 刘济生. 干细胞样记忆性T细胞在自身免疫性疾病中的研究进展[J]. 中南大学学报(医学版), XXXX, XX(XX): 1-7. DOI：10.11817/j.issn.1672-7347.XXXX.230051优先

LIU Zhichen, JIAO Qingqing, XIE Huanxia, LIU Jisheng. Research progress of stem cell-like memory T cells in autoimmune diseases[J]. Journal of Central South University. Medical Science, XXXX, XX(XX): 1-7. DOI：10.11817/j.issn.1672-7347.XXXX.230051 优先

摘要

干细胞样记忆性T细胞(Stem cell-like memory T cells，T

SCM

)是一种长寿的、具有持续自我更新能力及重建记忆、效应T细胞亚群的多分化潜能的记忆性T细胞亚群，在动物研究中的证据表明，T

SCM

细胞是记忆性 T 细胞系统中的最小分化细胞，具有类似干细胞的生物学特性，对于维持功能性免疫至关重要。由于T

SCM

细胞强大的免疫重建潜能，它在许多人类生理和病理过程中发挥着核心作用，相关研究表明，T

SCM

细胞在多种自身免疫性疾病的发生及发展中起重要作用。该综述阐述了T

SCM

细胞的表型及生物学特征，并对它们在自身免疫性疾病中的研究进展进行了总结和探讨，以期为临床医师和相关领域科研工作者提供参考。

Abstract

Stem cell-like memory T cells (T

SCM

)

this kind of cells is a memory T cell subset with characteristics of long life span

consistent self-renewing

and the multipotent capacity to reconstitute the memory and effector T cell subsets. The result of an animal experiments shows that it is the least differentiated cell in the memory T lymphocyte system

endowed with the stem cell–like ability

and it is essential for maintaining functional immunity. In addition

owing to their robust potential for immune reconstitution

they are central players in many physiological and pathological human processes. Many studies indicate that T

SCM

cells play an important role in the occurrence and development of various autoimmune diseases. In this article

we focused on the phenotypic and biological characteristics of T

SCM

cells and discussed the research progress of T

SCM

cells in autoimmune diseases.

关键词

干细胞样记忆性T细胞自身免疫性疾病细胞分化免疫治疗

Keywords

Stem cell-like memory T cells (TSCM)Autoimmune diseasesCell differentiationImmunotherapy

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