cGAS-STING通路与代谢性心血管疾病

丁慧晴; 周玉莹; 印旨意; 台适

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更新时间：2023-06-16

cGAS-STING通路与代谢性心血管疾病
cGAS-STING signaling pathway and cardiometabolic diseases
中南大学学报(医学版) 中南大学学报(医学版) 2023年页码：1-13
作者机构：

1.中南大学湘雅二医院心血管内科,长沙 410011
2.湘潭市中心医院心血管内科,湖南湘潭 411199
3.中南大学湘雅二医院输血科,长沙 410011
基金信息：
DOI：
中图分类号：
CSTR：
网络出版日期： 2023-06-16 ，

收稿日期： 2023-01-21 ，

丁慧晴, 周玉莹, 印旨意, 台适. cGAS-STING通路与代谢性心血管疾病[J]. 中南大学学报(医学版), XXXX, XX(XX): 1-13.

DING Huiqing, ZHOU Yuying, YIN Zhiyi, TAI Shi. cGAS-STING signaling pathway and cardiometabolic diseases [J]. Journal of Central South University. Medical Science, XXXX,XX(XX): 1-13.
丁慧晴, 周玉莹, 印旨意, 台适. cGAS-STING通路与代谢性心血管疾病[J]. 中南大学学报(医学版), XXXX, XX(XX): 1-13. DOI：10.11817/j.issn.1672-7347.XXXX.230028优先

DING Huiqing, ZHOU Yuying, YIN Zhiyi, TAI Shi. cGAS-STING signaling pathway and cardiometabolic diseases [J]. Journal of Central South University. Medical Science, XXXX,XX(XX): 1-13. DOI： 10.11817/j. issn. 1672-7347. XXXX. 230028优先

摘要

代谢性心血管疾病是糖脂代谢紊乱与心血管功能损害之间存在因果关联的临床常见综合征，但具体发病机制不清。cGAS-STING信号通路通过识别双链DNA调控固有免疫的激活。代谢性危险因素引起线粒体DNA、核DNA在胞质浓度上升以及内质网应激，驱动cGAS-STING通路的激活，从而触发反复无菌性炎症、细胞自噬水平上调、细胞衰老及细胞凋亡，最终表现为心血管不良结局的发生与发展。因此，靶向干预cGAS-STING信号通路或将成为治疗代谢性心血管疾病的崭新方式。

Abstract

Cardiometabolic disease is a common clinical syndrome with exact causal relationship between the aberrant of glucose and lipid metabolism and cardiovascular disfunction

but its pathogenesis is unclear. cGAS-STING signaling pathway regulates the activation of innate immunity by sensing intracellular double atranded DNA. Metabolic risk factors drive the activation of cGAS-STING pathway through mitochondrial DNA

nuclear DNA and endoplasmic reticulum stress. In addition

the activation of the cGAS-STING pathway triggers chronic sterile inflammation

excessive activate of autophagy

senescence and apoptosis in cardiovascular system related cells. These changes induced by cGAS-STING pathway might be implicated in the onset and deterioration of cardiometabolic disease. Therefore

the targeted intervention of cGAS-STING signaling pathway may become an emerging treatment for cardiometabolic disease.

关键词

cGAS-STING信号通路自噬衰老代谢性心血管疾病

Keywords

cGAS-STING signaling pathwayautophagysenescencecardiometabolic disease

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