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Journal Of C entral South University(Medica Science)
2018, Vol.43 Num.12
Online: 2018-12-28


 
1281 ZENG Zhengpeng, SUN Shenghua, XIE Lihua
Effect of miR-21 on autophagy, proliferation and apoptosis of macrophages induced by cigarette smoke extract
Objective: To explore the eff ects of miR-21 on macrophage autophagy, proliferation and apoptosis induced by cigarett e smoke extract (CSE). Methods: The cells was divided into a control group, a CSE interventine macrophage group (CSE group), and a miR-21 inhibitor+CSE intervention macrophage group (miR-21 inhibitor+CSE group). The expression of miR-21 in the 3 groups was detected by real-time PCR. The effects of miR-21 inhibitor on macrophage autophagy, proliferation and apoptosis were detected by Western blot, MTT assay and flow cytometry. Results: Compared with the control group, the levels of miR-21 and autophagy in the CSE group were significantly increased (both P<0.05). The expression of miR-21 in the miR-21 inhibitor+CSE group was significantly lower than that in the CSE group (P<0.05). Compared with the control group, the expressions of macrophage microtubule associated protein 1 light chain 3 alpha (LC3) and autophagy related 7 (ATG7) in the CSE group were increased, which was attenuated by miR- 21 inhibitor. Compared with the control group, the macrophage proliferation in the CSE group was inhibited by the miR-21, which could be reversed by adding miR-21 inhibitor; the proliferative rates in the miR-21 inhibitor+CSE group in 2, 3 or 4 days were increased by 1.41, 1.54 or 1.70 times compared with those in the CSE group (all P<0.05). Flow cytometry showed that the apoptosis rate in the control group was (2.57+1.35)%, which was (18.70+2.16)% in the CSE group and (6.28+1.08)% in the miR-21 inhibitor+CSE group (P<0.05). Conclusion: CSE intervention macrophage increase the autophagy and apoptosis of macrophages, decrease the cell proliferation by affecting the expression of miR-21 and the level of autophagy in macrophages.
2018 Vol. 43 (12): 1281-1287 [Abstract] ( 66 ) [HTML 1KB] [PDF 738KB] ( 262 )
1288 HUANG Qian1, LI Daiqiang2
Differential expression of serum miRNAs in patients with advanced non-small cell lung cancer treated by gifitinib before and after acquiring drug resistance
Objective: To explore the diff erential expression of serum miRNAs in patients of advanced nonsmall cell lung cancer (NSCLC) treated by gifi tinib before and aft er acquiring drug resistance. Methods: A total of 4 patients with advanced NSCLC from Affiliated Hospital of Yueyang Vocational Technical College, who acquired drug resistance during gefitinib therapy from June 2013 to June 2015, were enrolled. Serum samples were collected before treatment and after acquiring drug resistance. MicroRNA (miRNA) microarray was used to assess the levels and compositions of miRNAs in serum. Real-time RT-PCR was used to validate the results of miRNAs with significant differences in expression. The candidate miRNAs inhibitors and mimics were transfected into lung cancer cells by liposome, and the sensitivity of lung cancer cells to gifitinib was detected. Results: The miRNA microarray showed that there were significantly differential expression of miRNAs in serum of NSCLC patients after acquiring drug resistance, and 24 miRNAs were changed in more than 2-fold. Among them, 19 miRNAs were up-regulated and 5 miRNAs were down- regulated (both P<0.05). Especially, the expression of miR-21 in serum of NSCLC patients after obtaining resistance was up-regulated more than 10-fold compared with that before treatment. The results of RT-PCR was consistent with the results of miRNA microarray. The up-regulation of miR-21 in lung cancer cells could elevate the half maximal inhibition concentration (IC50) of gefitinib, and the down-regulation of miR-21 in lung cancer cells could reduce the IC50 of gefitinib (both P<0.05). Conclusion: There is differential expression of miRNAs in serum of NSCLC patients before treatment and after acquiring drug resistance during gefitinib therapy. The up-regulation of miR-21 may be involved in regulating the acquiring drug resistance of gefitinib.
2018 Vol. 43 (12): 1288-1293 [Abstract] ( 52 ) [HTML 1KB] [PDF 368KB] ( 189 )
1294 LIU Bohao1, WU Pengfei2, MEI Lin1, LUO Yong1, LI Hongxing1, MAO Xinzhan1
Differential expression of exosomal miRNAs in osteoblasts in osteoarthritis
Objective: To analyze the diff erentially expressed exosomal miRNAs in subchondral osteoblasts in patients with osteoarthritis (OA) and to investigate the key miRNAs potentially involved in the occurrence and progression of OA. Methods: Subchondral bones were harvested from 6 patients with OA. All subjects were divided into two groups which was based on the severity of joint wear: An OA group, severely worn side of subchondral bone, and a control group, less worn side of subchondral bone. Th e exosomes were extracted from osteoblast cells and their characteristics were identifi ed. Th en exosomal miRNAs were extracted and sequencing analysis was conducted to compare the expression in the two groups. The most differentially expressed ones (log2Ratio≥2) were subject to miRNA target prediction and quantitative reverse transcription PCR (RT-qPCR) to further quantify the difference. Results: Osteoblast extractions were confirmed to be exosomes, which were small doublemembranous vesicles with 30–200 nm in diameter and 50–150 nm in peak value of particle size under the scanning microscope. High-throughput sequencing revealed 124 miRNAs whose expression significantly increased in the OA group. The most differentially expressed one with maximum fold change was hsa-miR-4717-5p and its target gene was RGS2. RT-qPCR demonstrated hsa-miR-4717-5p expression in the OA group was relatively higher than that in the control group (2.243 vs 0.480, P<0.01). Conclusion: There is distinct difference in expression profiles of exosomal miRNAs in subchondral osteoblasts between patients with OA and normal subjects. Up-regulated expression of miRANs might participate in OA occurrance and progression.
2018 Vol. 43 (12): 1294-1300 [Abstract] ( 66 ) [HTML 1KB] [PDF 817KB] ( 215 )
1301 XIAO Bolin1, 2, CHEN Meifang1, YANG Mei1, XIAO Zhilin1
Effects of ATP on expression of inflammatory factors in endothelial progenitor cells induced by LPS and the mechanisms
Objective: To investigate the effects of adenosine triphosphate (ATP) on expression of infl ammatory factors induced by lipopolysaccharide (LPS) in endothelial progenitor cells (EPCs),and to elucidate the possible mechanisms. Methods: Mononuclear cells were isolated from human umbilical cord blood by density gradient centrifugation, RT-PCR was performed to detect the expression of inflammatory factors induced by LPS (1 mg/mL) in EPCs, the effect of low concentration (5 μmol/L) of ATP on expression of IL-1β, MCP-1 and ICAM-1, and the effect of different concentrations (5, 50 μmol/L) of ATP on the expression of Toll-like receptor (TLR) 4, myeloid differentiation primary response protein 88 (MyD88) and CD14. Western blot was performed to detect expression of TLR4 regulated proteins MyD88 and CD14 or to detect the low concentration (1, 5 μmol/L) of ATP on the expression of TLR4, MyD88 and CD14 and the NF-κB signaling pathway. Results: EPCs highly expressed TLR4, and its ligand LPS (1 mg/mL) significantly upregulated mRNA expression of IL-1β, MCP-1 and ICAM-1 and protein expression of MyD88 and CD14 in a time-dependent manner (P<0.01), accompanied by activation of ERK and NF-κB signal pathway. ATP at low concentration (5 μmol/L) significantly inhibited LPS-induced mRNA expression of IL-1β, MCP-1 and ICAM-1(P<0.05), downregulated the LPS-induced protein expression of TLR4, MyD88 and CD14 in EPCs (P<0.05), and suppressed LPS-induced activation of NF-κB signaling pathway (P<0.05). Conclusion: ATP at low concentration may suppress LPS-induced expression of inflammatory factors in EPCs through negative regulation of the TLR4 signaling pathway.
2018 Vol. 43 (12): 1301-1308 [Abstract] ( 49 ) [HTML 1KB] [PDF 831KB] ( 171 )
1309 ZHU Fang1, ZHANG Baixue2, ZHU Wenhui1
Evaluation of the volume and function of left atrial appendage and left atrium in patients with atrial fibrillation by three-dimensional transesophageal echocardiography and transthoracic echocardiography
Objective: To evaluate the volume and function of left atrium and left atrial appendage in patients with atrial fibrillation by three-dimensional transesophageal echocardiography and transthoracic echocardiography. Methods: A total of 112 patients with atrial fibrillation were divided into two groups: a paroxysmal atrial fibrillation (ParAF) group (n=80) and a persistent atrial fibrillation (PerAF) group (n=32). Control group was people without atrial fibrillation (n=40). Clinical data of the participants were collected. Left atrial dimension (LAD), left atrial volume (LAV), left ventricular enddiastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) were measured by transthoracic echocardiography, while left atrial appendage peak emptying flow velocity (LAAeV), left atrial appendage peak filling flow velocity (LAAf V), left atrial appendage maximum volume (LAAVmax) and left atrial appendage minimum volume (LAAVmin) were measured by threedimensional transesophageal echocardiography. Left atrial volume index (LAVI), left ventricular ejection fraction (LVEF) and left atrial appendage ejection fraction (LAAEF) were calculated. Results: Compared with the control group, LAAEF, LAAeV and LAAf V in the ParAF group were decreased obviously, while LAD, LAV, LAVI, LAAVmax and LAAVmin in the ParAF group were increased obviously (P<0.05). Compared with the ParAF group, LAAEF, LAAeV and LAAf V in the PerAF group were also decreased obviously, and LAD, LAV, LAVI, LAAVmax and LAAVmin in the ParAF group were also increased obviously (P<0.05). There was no statistically significant difference in LVEDV, LVESV, LVEF between the ParAF group and the PerAF group (P<0.05). Conclusion: Left atrium and left atrial appendage were enlarged and the function of left atrial appendage was declined in patients with AF, and the changes were more obvious in patients with PerAF compared with patients with ParAF by three-dimensional transesophageal echocardiography and transthoracic echocardiography.
2018 Vol. 43 (12): 1309-1314 [Abstract] ( 50 ) [HTML 1KB] [PDF 523KB] ( 209 )
1315 MAO Yitao1, LIAO Weihua1, CAO Dong1, ZHAO Luqing2, 3, WU Xunhua1, KONG Lingyu1, ZHOU Gaofeng1, ZHAO Yuelong4, WANG Dongcui1, 5
An artificial neural network model for glioma grading using image information
Objective: To explore the feasibility and efficacy of artificial neural network for differentiating high-grade glioma and low-grade glioma using image information. Methods: A total of 130 glioma patients with confirmed pathological diagnosis were selected retrospectively from 2012 to 2017. Forty one imaging features were extracted from each subjects based on 2-dimension magnetic resonance T1 weighted imaging with contrast-enhancement. An artificial neural network model was created and optimized according to the performance of feature selection. The training dataset was randomly selected half of the whole dataset, and the other half dataset was used to verify the performance of the neural network for glioma grading. The trainingverification process was repeated for 100 times and the performance was averaged. Results: A total of 5 imaging features were selected as the ultimate input features for the neural network. The mean accuracy of the neural network for glioma grading was 90.32%, with a mean sensitivity at 87.86% and a mean specificity at 92.49%. The area under the curve of receiver operating characteristic curve was 0.9486. Conclusion: As a technique of artificial intelligence, neural network can reach a relatively high accuracy for the grading of glioma and provide a non-invasive and promising computer-aided diagnostic process for the pre-operative grading of glioma.
2018 Vol. 43 (12): 1315-1322 [Abstract] ( 51 ) [HTML 1KB] [PDF 753KB] ( 204 )
1323 JIA Yan, FU Hao, LI Na, KA NG Qian, SHENG Jianqiu
Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome
Objective: To explore the clinical features, pathological features, gene test results, diagnosis, treatment and prognosis of Peutz-Jeghers syndrome(PJS). Methods: We retrospectively analyzed clinical data of 46 hospitalized cases of PJS during 2007 and 2017. Results: All 46 patients had mucocutaneous melanin pigmentation and multiple gastrointestinal polyposis. The pigmentation was first noticed often within 5 years old, and 14 cases had family history. The clinical manifestations mainly included black spots, abdominal pain, hematochezia, and anemia. Histological examinations showed that 20 patients were classifi ed as hamartomatous polyps,18 as adenomatous polyps, 14 as inflammatory polyps, and 10 as zigzag polyps. Eleven patients sequenced a panel of 20 genes previously associated with colorectal cancer (CRC) by next-generation sequencing, and the results showed 5 patients with gene mutations, and 3 of them with intussusception and surgical histories were found to have pathogenic germline mutations in the STK11 gene. Endoscopic treatment was the main therapy, but endoscopy combined with laparoscopy or surgical treatment was performed when complications occurred or the polyp was too large. Malignant tumors were found in 3 patients during follow-up. Conclusion: PJS is a hereditary disease which is characterized by spots of the skin or mucosa and gastrointestinal multiple polyps. The main pathological features are hamartoma and adenoma. The risks for intussusception and surgical operation are found to be high in the patients with pathogenic germline mutations in the STK11 gene. Endoscopic treatment is the main therapy. PJS patients should be followed up regularly due to the increasing risk for cancer and being easily to relapse.
2018 Vol. 43 (12): 1323-1327 [Abstract] ( 67 ) [HTML 1KB] [PDF 1118KB] ( 200 )
1328 ZHAO Lijuan, CHEN Lizhang, WANG Tingting, CHEN Letao, ZHENG Zan, ZHANG Senmao, YE Ziwei, QIN Jiabi
Impact of in vitro fertilization-embryo transfer on adverse pregnancy outcomes: A prospective cohort study
Objective: To evaluate whether the in vitro fertilization-embryo transfer (IVF-ET) procedures could increases the risks of adverse pregnancy outcomes (APOs) in off spring. Methods: A hospital-based prospective cohort design was conducted, which contained a control group of singleton pregnancies with indicators of subfertility who were still conceived naturally aft er using simple medical treatment (e.g. minimal medical intervention or ovulation induction), and an exposure group consisted of singleton pregnancies who had a history of infertility and IVFET treatment. All factors different between two groups in the univariate analysis were included in the multivariable logistic regression to evaluate the independent effect of IVF-ET procedures themselves on APOs. Results: After controlling for confounding factors by using multivariate logistic regression analysis, our results showed that pregnancies after IVF-ET experienced a higher risk of preterm birth (OR=1.28, 95% CI 1.05 to 1.56), low birth weight (OR=1.69, 95% CI 1.27 to 2.31), perinatal mortality (OR=5.33, 95% CI 2.44 to 11.81), and congenital malformations (OR=1.83, 95% CI 1.12 to 2.94). Conclusion: The IVF-ET operational factors may increase the risk of APOs.
2018 Vol. 43 (12): 1328-1336 [Abstract] ( 61 ) [HTML 1KB] [PDF 425KB] ( 199 )
1337 ZHOU Jiebin1, LI Qian1, GONG Guozhong2, GONG Huanyu3, HOU Zhouhua1
Analysis of prognostic factors and construction of a logistic regression model for patients with drug-induced liver failure
Objective: To explore the prognostic factors for patients with drug-induced liver failure (DILF) and construct a logistic regression model (LRM). Methods: A retrospective analysis of clinical data was performed in 183 hospitalized patients, who were diagnosed with DILF in Xiangya Hospital, the Second Xiangya Hospital and the Third Xiangya Hospital, Central South University from January 2009 to January 2018. The patients were divided into an improved group (n=67) and an ineffective group (n=116) according to their prognosis. Univariate analysis was performed to screen for possible prognostic factors such as age, Tbil, SCr, PT and complications. According to the results of univariate analysis, the multivariate analysis was performed to determine the independent prognostic factors and construct a LRM. The LRM was compared with the model for end-stage liver disease (MELD), the predictive value of LRM and MELD was evaluated by receiver operating characteristic curve (ROC), the parameters such as area under the ROC (AUC) and total accuracy were compared between the 2 models and verified by another independent sample. Results: According to univariate analysis, there was significant differences in age, clinical type, hepatic encephalopathy, hepatorenal syndrome, WBC count, the ratio of aspartic acid transaminase (AST) to glutamine transaminase (ALT) (AST/ALT), Tbil, SCr, PT and alpha-fetoprotein (AFP) between the 2 groups (all P<0.05). Multivariate analysis revealed that: AFP, PT, AST/ALT, hepatic encephalopathy and hepatorenal syndrome were independent prognostic factors for DILF, which could be applied to constructing a LRM. The AUC of LRM and MELD was 0.917 (95% CI 0.876 to 0.959) and 0.709 (95% CI 0.633 to 0.786) respectively, the total accuracy rate of prediction for the LRM and the MELD was 86.7% and 68.3% respectively, there was significant difference in AUC and total accuracy rate between the LRM and the MELD (P<0.05). LRM was superior to MELD. Conclusion: AFP, PT, AST/ALT, hepatic encephalopathy and hepatorenal syndrome were independent prognostic factors for DILF; the LRM can well predict the prognosis in the DILF patients, which is superior to the MELD.
2018 Vol. 43 (12): 1337-1344 [Abstract] ( 55 ) [HTML 1KB] [PDF 457KB] ( 232 )
1345 YAN Wenguang1, LI Xuhong1, SUN Shaodan1, XIANG Yali2, ZHOU Yanhua1, ZENG Xiaoling1, XIE Fen1, JIANG Hongyu1, LIU Qianyu1, XIANG Juan1
Risk factors for female pelvic organ prolapse and urinary incontinence
Objective: To explore the risk factors for and the pathogenic mechanisms of pelvic organ prolapse and urinary incontinence. Methods: A total of 2 668 females who completed pelvic floor functional detection from July 2014 to October 2015 in the Physical Examination Center of the Third Xiangya Hospital of Central South University. The patients were divide into 4 groups: an urinary incontinence group, an organ prolapse group, an organ prolapse with urinary incontinence group, and a normal group. We compared the age, BMI, menopause, gravidity and parity, delivery pattern, the coordination of pelvic floor and abdominal muscles among the 4 groups. Results: There were statistical differences in age and BMI values among the 4 groups (P<0.05). There were statistical differences in menopause rate, gravidity and parity history among the normal group and the other 3 groups (P<0.05), and between the organ prolapse group and the organ prolapse with urinary incontinence group (P<0.05). However, the urinary incontinence group was not statistically different from the organ prolapse group and the normal group (P>0.05). In the mode of delivery, there were statistical difference among the normal group and the other 3 groups (P<0.05), and between the organ prolapse group with urinary incontinence group and the organ prolapse or the urinary incontinence group (P<0.05). There was no significant difference between the urinary incontinence group and the organ prolapse group (P>0.05). Among the 4 groups, the normal group was the best one in coordination between pelvic floor and abdominal muscles, following by the organ prolapse group, the pelvic organ prolapse group and the urinary incontinence group. Conclusion: Aging, menopause, number of pregnancies and delivery, BMI, and mode of delivery all affect the occurrence of pelvic organ prolapse and urinary incontinence. Females with urinary incontinence or organ prolapse are not good in coordination between the pelvic floor and abdominal muscles.
2018 Vol. 43 (12): 1345-1350 [Abstract] ( 59 ) [HTML 1KB] [PDF 348KB] ( 182 )
1351 LI Li1, 2, JIANG Xianyin2, CHEN Zhe3, WU Ying2, LI Yinglan2, FAN Xuegong1, 2
Evaluation of intervention program for risk behaviors of unintentional injury among school age children
Objective: To develop an intervention protocol for children's unintentional injury risk behaviors, and to evaluate the feasibility of the protocol. Methods: By theoretically analyzing the influential factors for children's unintentional injury risk behaviors, children's cognitive development characteristics and the social learning theory, an intervention protocol was established on the basis of changing the unintentional injury attribution and negative information transmission of risk behavior consequences. A primary school in Changsha city was selected by random cluster sampling. A community-based randomized controlled trial was conducted on the selected students once a week for 5 consecutive weeks. The scores of unintentional injury risk behavior before intervention, 3 months and 6 months after intervention, and the frequency before intervention and 6 months after intervention, were collected and compared. Results: A total of 194 children were included in the study: 98 in the intervention group; 96 in the control group; 96 (49.5%) boys and 98 (50.5%) girls between 7 and 8 years old. The scores of unintentional injury risk behavior for children in the intervention group at 3 and 6 months after intervention were 14.42±5.67 and 14.14±8.95, respectively, lower than those before the intervention (16.85±8.48) and in the control group (P=0.001). The number of minor unintentional injuries in the intervention group decreased from 119 to 56, and the number of children suffering 2 or more injuries dropped from 34 to 10 (P<0.001) at 6 months after the intervention, while both of them were lower than that in the control group (P=0.011). Similar changes were observed in some slight or more serious unintentional injuries (P=0.030). Conclusion: The protocol for changing the attribution to unintentional injury and negative information transmission for risk behavior consequences was proved to effectively reduce children’s unintentional injury risk behaviors and relevant events.
2018 Vol. 43 (12): 1351-1357 [Abstract] ( 57 ) [HTML 1KB] [PDF 454KB] ( 186 )
1358 LIU Yaqiong, ZHAO Wang, ZHAO Shuiping
Apolipoprotein A5 gene polymorphisms affect triglyceride metabolism and atherosclerotic cardiovascular diseases

Apolipoprotein A5 (Apo A5) is a novel member in apolipoprotein family, which is proven to be an important regulator in triglyceride metabolism, especially in adjusting the TG content in plasma. Apo A5 gene polymorphisms affect triglyceride metabolism and atherosclerotic cardiovascular diseases. Th e research focuses on –1131T>C, c.56C>G, and c.553G>T.

2018 Vol. 43 (12): 1358-1363 [Abstract] ( 66 ) [HTML 1KB] [PDF 409KB] ( 178 )
1364 LI Yamin1,2, QIAO Jianfeng1,2, ZHANG Wenxuan3,4, PENG Zhenyu3,4
Research progress in AMP-activated protein kinase and sepsis-induced cardiac dysfunction
Sepsis-induced cardiac dysfunction is a serious complication of sepsis with no eff ective treatment. AMP-activated protein kinase (AMPK) is a regulator for energy metabolism in cells and plays a key role in the energy balance. Recent studies have shown that AMPK exerted a protective eff ect on sepsis-induced cardiac dysfunction, which was related to the regulation of inflammation, endothelial cells injury, energy metabolism, myocardial cells apoptosis and autophagy. Th erefore, AMPK is a therapeutic target for sepsis-induced cardiac dysfunction.
2018 Vol. 43 (12): 1364-1368 [Abstract] ( 67 ) [HTML 1KB] [PDF 306KB] ( 170 )
1369 LONG Ying, CHEN Weilin, DU Qian, ZUO Xiaoxia, ZHU Honglin
Research progress in epigenetic studies on systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease with unknown etiology, characterized by vasculopathy, infl ammation, and extensive fi brosis in the skin and organs. Fibrosis is the hallmark of SSc and contributes to its high mortality. In recent years, with the in-depth study of the epigenetics of SSc (DNA methylation, histone modifi cation, and non-coding RNA), the DNA methylation and miRNA has been the most widely studied. Abnormal DNA methylation can infl uence the function of vascular endothelial cells, CD4+ T cells, and fibroblasts in SSc. MiRNAs in serum is closely related to autoantibodies, SSc disease activity and complications, and miRNAs in fi broblasts can directly aff ect the activation of fi broblasts.
2018 Vol. 43 (12): 1369-1375 [Abstract] ( 65 ) [HTML 1KB] [PDF 316KB] ( 164 )
1376 OUYANG Qianying1, 2, LIU Yujie1, 2, LIU Yingzi1, 2
Research progress of copper transporter 1 in platinum-based chemotherapy
Platinum drugs are widely used in the treatment of various solid tumors, but their resistance to platinum is the most significant obstacle to successful treatment. Copper transporter 1 (CTR1) is the specific transporter for copper, and it mainly locates at the plasma membrane and plays a role in pumping copper into the cell. CTR1 is also the major platinum influx transporter and plays a key role in platinum resistance. Th e expression, polymorphism, and degradation of CTR1 aff ect platinum resistance in tumors. Th erefore, CTR1 may be a potential predictive biomarker of platinum resistance and a therapeutic target for overcoming platinum resistance.
2018 Vol. 43 (12): 1376-1379 [Abstract] ( 60 ) [HTML 1KB] [PDF 272KB] ( 170 )
1380 ZHAN Yi1, XIAO Rong1, ZHANG Zhiwei2
Advancement in phodynamic therapy for non-neoplastic skin diseases
Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, acne, rosacea, chronic skin ulcer, fungal diseases, keloid, and so on. Here is the review on the advancement in photodynamic therapy for non-neoplastic skin diseases.
2018 Vol. 43 (12): 1380-1383 [Abstract] ( 63 ) [HTML 1KB] [PDF 289KB] ( 167 )
1384 YANG Haili1, 2, ZOU Yuan1, ZOU Haixiao1, 3
Non-Hodgkin’s lymphoma in the jaw: A report of 3 cases and literature review
To investigate the clinical manifestations, imaging features, and diagnosis for non-Hodgkin’s lymphoma in the jaw, we retrospectively analyzed 3 cases of non-Hodgkin’s lymphoma in the jaw and reviewed relevant literature. Th ree patients’ lesion occurred in the maxilla with early painless masses. Two patients were diagnosed as diff use large B-cell lymphoma via biopsy, and one patient underwent maxillofacial resection with pathological examination which showed plasmaoblastoma lymphoma. Non-Hodgkin’s lymphoma in the maxilla is rare and easily misdiagnosed due to the atypical clinical features. Biopsy at the early stage of the lesion and pathological examination can assist the diagnosis for non-Hodgkin’s lymphoma.
2018 Vol. 43 (12): 1384-1388 [Abstract] ( 67 ) [HTML 1KB] [PDF 949KB] ( 196 )
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2018 Vol. 43 (12): 201812-201812 [Abstract] ( 51 ) [HTML 1KB] [PDF 14540KB] ( 202 )
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