中南大学学报(医学版)
 
Home | About Journal | Editorial | Instruction | Subscription | Advertisement | News | Download | Message | Contact Us | Chinese
 
  Office  
Online Submission
Manuscript Tracking
Peer Review
Office Work
Editor-in-chief
  Quick Search   
 
 Adv Search   
  Journal
      Current Issus
      Archive
  Visitors  
 Total visitors     
  Links
s
International Journal of Pathology and Clinical Medicine
Fudan University Journal of Medical Science
Chinese Journal of General Surgery
Chinese Journal of Contemporary Pediatrics
Chinese Journal of Arteriosclerosis
DXY
pubmed
 
 
 
Journal Of C entral South University(Medica Science)
2019, Vol.44 Num.2
Online: 2019-02-28


 
117 SHEN Maolei1, QIAN Biao1, XU Hao2, FU Jiahao1, WANG Yuchen1, WANG Qinzhang1
Effect of recombinant lentivirus of SCL gene on expression of c-kit protein in interstitial cells of Cajal under high glucose condition

Objective: To determine the effect of a recombinant lentivirus containing human stem cell
leukemia (SCL) gene on the expression of c-kit protein in damaged interstitial cells of Cajal (ICC)
under high glucose condition.
Methods: Aft er isolation of ICC, the cells were cultured for 24 hours until the cells were adherent.
Aft er identifi cation by inverted microscope and immunofl uorescence, ICC cells were divided into two groups: A control group and a high glucose group. The control group was added with a medium
containing 5 mmol/L of glucose. The high glucose group was added with a medium containing
20 mmol/L of glucose. After 48 h of continuous cultivation, the high glucose group was divided
into 3 subgroups: A blank group, an empty lentivirus group, and an experimental group. The blank
group, the empty lentivirus group, and the experimental group were added a medium containing
PBS solution, empty lentivirus, and a recombinant lentivirus containing the SCL gene with a
glucose concentration of 5 mmol/L, respectively. The cultures were incubated for 24 and 48 h. The
expression of c-kit protein in ICC in each group was detected by Western blot.
Results: After 24 or 48 h, the expression of c-kit protein in ICC was significantly lower in the blank
group and the lentivirus group than that in the control group, and the expression of c-kit protein in
ICC was significantly higher in the experimental group than that in the blank group and the empty
lentivirus group, but it was still lower than that in the control group (all P<0.05).
Conclusion: The recombinant lentivirus of SCL gene can up-regulate the expression of c-kit
protein in functionally impaired ICC under high glucose condition.

2019 Vol. 44 (2): 117-121 [Abstract] ( 57 ) [HTML 1KB] [PDF 512KB] ( 694 )
122 LIU Jianyun1, XIE Xin2, WU Ping1, XIONG Jianjun1, 2
Ubiquitin specific peptidase 22 regulates the transcription activity of mitogen-activated protein kinase kinase 6 gene

Objective: To clone human mitogen-activated protein kinase kinase 6 (MKK6) gene promoter and
explore its transcription activity by ubiquitin specifi c peptidase 22 (USP22).
Methods: MKK6 gene promoter was amplified by PCR and two bases mutation within USP22
binding site was subsequently introduced. The wild type and mutant MKK6 promoter were
inserted into the luciferase report vector pGL3-Basic, respectively. Recombinant plasmids were cotransfected
with plasmid pRL-TK into HeLa cells, and the luciferase activities were measured by
dual luciferase reporter system. Furthermore, the direct interaction between USP22 and MKK6 promoter was detected by chromatin immunoprecipitation (ChIP) assay. Finally, the MKK6
transcription activity was measured after knockdown of USP22.
Results: The recombinant luciferase report vectors containing wild or mutant type of MKK6
promoter were successfully constructed. Mutation of USP22 binding site resulted in decrease of
MKK6 promoter-driven luciferase activity in HeLa cells (P<0.05). USP22 could interact directly
with MKK6 promoter. Down-regulation of USP22 led to the decreased MKK6 mRNA expression
(P<0.05).
Conclusion: USP22 could regulate the transcription activity of MKK6 gene in HeLa cells.

2019 Vol. 44 (2): 122-127 [Abstract] ( 51 ) [HTML 1KB] [PDF 2264KB] ( 569 )
128 PAN Bingbing1, ZHOU Yong2, KONG Gaoyin3, LI Ping2, GUO Qulian1, GUAN Chaxiang2
Aucubin alleviates lipopolysaccharide-induced acute lung injury in mice

Objective: To investigate the effect of prophylactic aucubin (AU) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice.

Methods: Male BABL/c mice were randomly divided into a control group, an ALI group, and
an AU treatment group, 16 mice in each group. ALI mice were injected with LPS (5 mg/kg,
intratracheal injection), and AU (10 mg/kg) was injected intraperitoneally 30 min ahead. After LPS
injection for 6 hours mice were sacrificed, the morphological changes of lung tissues were detected
by HE staining and the lung injury score was obtained. The mRNA expression of tumor necrosis
factor-α (TNF-α) and interleukin 10 (IL-10) in lung tissue was detected by real-time PCR. The
total protein and lactate dehydrogenase (LDH) activity, the cell count, and the protein content of
TNF-α and IL-10 in the mouse bronchoalveolar lavage fluid (BALF) were detected.
Results: Compared with ALI mice, the pathological damage score of lung tissue was significantly
reduced in the AU group, the total number of BALF cells, neutrophils, and macrophages were
significantly decreased, LDH activity and the total protein content were also significantly decreased
(all P<0.01). In addition, AU can reduce the mRNA and protein expression of TNF-α in lung of
ALI mice, and increase the mRNA and protein expression of IL-10 (all P<0.01).
Conclusion: AU can reduce LPS-induced ALI in mice.

2019 Vol. 44 (2): 128-133 [Abstract] ( 43 ) [HTML 1KB] [PDF 629KB] ( 76 )
134 CHEN Xingwu, QING Lilong, SUN Zhengui, XING Min, ZANG Leilei, WANG Hanli
Airway epithelial cells increase macrophage chemotaxis and inflammatory cytokine secretion under hypoxic conditions

Objective: To investigate the effects of airway epithelial cells on macrophages chemotaxis and
infl ammatory cytokine expression under hypoxic conditions.
Methods: Human bronchial epithelial cells (HBE) treated with diff erent concentrations (0, 100, 200, 400, 800 μmol/L) of CoCl2 or transfected with HIF-1α siRNA were co-cultured with THP-
1-derived M1 macrophages or M2 macrophages. The chemotactic effects on macrophages were
analyzed by Transwell assay. The levels of TNF-α, IFN-γ, IL-4, IL-13 and IL-10 in the supernatants
of macrophages were detected by ELISA, and HIF-1α or Cav-1 mRNA expression in HBE or
macrophages was detected by RT-qPCR.
Results: HBE cells promoted macrophages chemotaxis in a time- and concentration-dependent
manner. Compared to un-transfected group, the chemotactic ability of HBE transfected with HIF-
1α siRNA was significantly weakened (P<0.01). Under the same culture conditions, the chemotaxis
of M2 macrophages was greater than that in THP1-derived M1 macrophages. The concentrations of
TNF-α, IFN-γ, IL-4, IL-13 and IL-10 in the supernatants of macrophages were increased in a timeand
concentration-dependent manner. The concentrations of TNF-α and IFN-γ were increased
further after co-culturing for 8 and 12 h; while IL-4, IL-13 and IL-10 concentrations were increased
further during 24 h of co-culture. The levels of cytokines in the supernatants of macrophages cocultured
with HBE and transfected with HIF-1α siRNA were significantly lower than those in untransfected
cells (P<0.05 or P<0.01). The reduction of TNF-α or IFN-γ was more obvious. The
expression of HIF-1α or Cav-1 mRNA in HBE or macrophages was increased in a concentrationdependent
manner after 8 or 12 h co-culture, which was significantly reduced when HBE was
transfected with HIF-1α siRNA.
Conclusion: Airway epithelial cells can enhance macrophages chemotaxis and pro-inflammatory
cytokines expressions under hypoxic condition. HIF-1α and Cav-1 may be the important mediators
in these processes.

2019 Vol. 44 (2): 134-143 [Abstract] ( 43 ) [HTML 1KB] [PDF 1535KB] ( 71 )
144 WANG Yuan, ZHANG Dingwei, HUO Jia, HU Gang, WU Jiawen
Effects of chemerin/chemR23 axis on Th9/Treg in patients with psoriasis

Objective: To investigate the eff ects of chemerin on helper T cells 9 (Th 9)/regulatory T cells (Treg)
in patients with psoriasis and the potential molecular mechanisms.
Methods: Twenty-fi ve patients with psoriasis and twenty healthy volunteers were selected for this
study. CD4+ T cells were isolated from peripheral blood of samples by magnetic bead separation.
Th e levels of chemerin and its receptor chemR23 were detected by real-time RT-PCR and ELISA.
CD4+ T cells isolated from the healthy volunteers were treated with different concentrations of
chemerin (50, 100, 150, 200 ng/mL), then cell viability was detected by MTT assay. Th e expression
of infl ammatory molecules and Th 9/Treg were detected by ELISA and fl ow cytometry, respectively.
Results: The expressions of chemerin and chemR23 in peripheral blood from patients with psoriasis were higher than those in healthy control (both P<0.05). The Th9/Treg was higher in
patients with psoriasis than that in healthy control (P<0.05). After treating CD4+ T cells with
150 ng/mL of chemerin, the levels of IL-6, IL-9 and IL-17 were increased significantly (all P<0.05).
Additionally, Th9/Treg was increased (P<0.05) and the cell balance was disrupt. However, the
effects of chemerin on CD4+ T cells were reversed by silencing of chemR23 (all P<0.05).
Conclusion: Chemerin may regulate the immune balance for Th9/Treg in CD4+ T cells from
patients of psoriasis.

2019 Vol. 44 (2): 144-149 [Abstract] ( 33 ) [HTML 1KB] [PDF 661KB] ( 72 )
150 LIU Zhiyan1, RA O Zhen2, SHENG Xiaowu1, LONG Ying1, ZHOU Xiao1
Effect of adipose-derived stem cells on radiation-induced acute skin injury in rats

Objective: To investigate the eff ect of adipose-derived stem cells (ADSCs) on radiation-induced skin injury in SD rats.
Methods: Radioactive particles 192Ir were used to irradiate the left medial thigh skin of SD rats,
and the irradiation dose was at 90 Gy. Then, the rats were randomly allocated into a control group
and a treatment group (each n=9). After the irradiation, the control group was injected with
60 μL PBS and the treatment group was injected with 60 μL ADSCs in irradiated skin. The progress
of skin damage and healing was observed and photographed every day. Twenty-eighth days
after the irradiation, the irradiated skin tissue was taken from the left thigh, and then fixed with
formaldehyde fixative solution. At the same time, the skin tissue of the corresponding part of the
normal group (n=9) that was not irradiated was also taken. After sampling, embedding and slicing,
immunohistochemical staining was used to compare the levels of α-smooth muscle actin (α-SMA),
and HE staining was used to compare pathological features of the skin.
Results: Radioactive particle 192Ir caused the development of III or IV radioactive skin damage.
The score of the treatment group was significantly lower than that of the control group. The wounds
of the treatment group were basically healed at 28 days, while the ulcer of the control group was
unhealed. So, the healing time was shorter in the treatment group. The expression of α-SMA in
the skin of the two groups was increased after the radiotherapy. By analyzing the pathological
microstructure image, we found that the thickness of epidermis in the control group was greater
than that in the treatment group, while the vascular density in the treatment group was greater than
that in the control group (all P<0.05).
Conclusion: Radioactive particles 192Ir can cause skin damage, while the adipose-derived stem cells
might alleviate radiation-induced skin injury and promote ulcer healing by promoting angiogenesis.

2019 Vol. 44 (2): 150-157 [Abstract] ( 42 ) [HTML 1KB] [PDF 2266KB] ( 85 )
158 PENG Zhaoqun, LIU Nenghui
Cumulative live birth rates after frozen embryo transfer and fresh embryo transfer with oocyte numbers more than 15

Objective: To compare the cumulative live birth rates (CLBR) and the incidence of ovarian
hyperstimulation syndrome (OHSS) between fresh embryo transfer (ET) and frozen ET (the
freeze-all policy), when oocyte numbers are more than 15 in the first treatment of in vitro
fertilization or intracytoplasmic sperm injection, and to evaluate the benefi ts of the freeze-all policy.
Methods: We retrospectively analyzed clinical data of 2 842 patients whose oocytes numbers were
more than 15, including 1 095 frozen ET patients and 1 747 fresh ET patients. Th e patients general
data, a baseline features, CLBR, and the incidence of OHSS were compared between the 2 groups.

Results: There were 598 patients in the 2 groups after they experienced the propensity score
matching. No significant differences were found in age, infertility causes, body mass index, basal
follicle stimulating hormone level, the total days and total dose of using gonadotrophin (Gn)
between the 2 groups (all P>0.05). The CLBR of the freeze-all cycles increased along with the
number of oocytes (P>0.05), and the oocyte numbers were greater in freeze-all group than those
of the fresh ET group (P<0.001). There was no significant difference in CLBR after one complete
cycle between the 2 groups (P>0.05), but after the first embryo transfer cycle, the CLBR in freezeall
group was higher than that in the fresh ET cycle group (P<0.05). The incidence of OHSS in
patients with freeze-all was significantly lower than that in the patiants with fresh ET (P<0.05).
Conclusion: Patients with oocytes over 15 and OHSS tendency who accepted the freeze-all
strategy can help them to prevent OHSS and they have a higher CLBR than fresh ET cycles.

2019 Vol. 44 (2): 158-163 [Abstract] ( 39 ) [HTML 1KB] [PDF 356KB] ( 77 )
164 YUAN Yunyi, TU Jingqiu, FAN Jiaqian, LEI Yonghua
Three-dimensional analysis for changes in dentigerous cyst-associated maxillary canines after marsupialization in adolescents
Objective: To observe three-dimensional changes of dentigerous cyst-associated maxillary canines (DCAMC) in adolescents after marsupialization by using cone beam computed tomography (CBCT). Methods: A total of 34 DCAMC patients with dentigerous cyst aged 10–14 were divided into central type and lateral type, while canines on the non-cyst side served as a control. A threedimensional reference frame was set up to analyze the position, angle changes and infl uential factors for DCAMC by using CBCT before operation and in 3–6 month after operation. Results: 1) Compared with pre-operation, there was significant vertical movement in DCAMC after marsupialization. Tip of tooth moved labially while tooth axis inclined mesiodistally; 2) Horizontal, vertical movement and mesiodistal inclination of DCAMC were significantly greater than those in the health side; 3) Compared with the lateral type DCAMC, the central type DCAMC showed a significant changes in labial inclination; 4) Horizontal movement, mesiodistal and labial inclination of lateral type DCAMC were all evidently greater than those of the central type DCAMC; 5) Vertical movement and inclination of DCAMC after marsupialization were significantly correlated to the time interval (r=0.354, 0.374, both P<0.05), while vertical movement of cuspid in health side was significantly negative correlated with the patients’ age and the level of root formation (r=–0.506, –0.721, both P<0.01). Conclusion: DCAMC in adolescents can obtain obvious changes in position and angles after marsupialization regardless of the level of root formation, which is beneficial for further orthodontic treatment.
2019 Vol. 44 (2): 164-172 [Abstract] ( 32 ) [HTML 1KB] [PDF 1654KB] ( 80 )
173 WANG Shaojuan1, TANG Xiaowen1, WANG Zhongqiu1, WANG Hao2
Value of magnetic resonance diffusion-weighted imaging for evaluating the inflammatory activity of perianal Crohn’s fistula
Objective: To explore the value of magnetic resonance diff usion-weighted imaging (MR-DWI) for evaluating infl ammatory activity of perianal Crohn’s fi stula. Methods: A total of 55 patients, who were diagnosed as perianal Crohn’s fi stula by surgery and/ or endoscopy, were assessed retrospectively. All patients, underwent pelvic magnetic resonance imaging (MRI) before and 32 weeks aft er the treatment, were divided into 2 groups according to their response to treatment: an eff ective group (34 cases) and an ineff ective group (21 cases). Th e MRI images of patients in the 2 groups were analyzed. Th e changes of apparent diff usion coeffi cient (ADC) values before and after treatment in the 2 groups were measured and compared by a paired t-test. An MRI-based score of perianal Crohn’s disease severity was calculated as a reference standard, and the correlation between the ADC value and the MRI-based score was analyzed by using a Pearson correlation coefficient method. Results: In the effective group, the ADC values after therapy were significantly greater than those before therapy (P<0.05), but in the ineffective group, there was no significant difference in the ADC value between after and before therapy (P>0.05). There was a strong negative correlation between the ADC values (after and before therapy) and the MRI-based scores in all the patients [in the effective group alone (r=–0.672, P<0.01) or in the effective group + the ineffective group (r=–0.638, P<0.01)]. Conclusion: Changes in the ADC values of perianal fistula are related to the fistula activity. MRDWI and ADC value can accurately evaluate the inflammatory activity of perianal Crohn’s fistula.
2019 Vol. 44 (2): 173-179 [Abstract] ( 29 ) [HTML 1KB] [PDF 766KB] ( 73 )
180 TIAN Jing, LIANG Pengfei, ZHANG Pihong, LIU Zan, ZHOU Jie, REN Licheng
Experience of diagnosis and treatment for 89 patients with Marjolin’s ulcers in lower limbs
Objective: To summarize the clinical features of Marjolin’s ulcers in lower limbs and the diagnosis and treatment methods for it. Methods: The clinical data of 89 patients with lower limbs Marjolin’s ulcers, who were treated in Xiangya Hospital, Central South University from Jan 1998 to Dec 2017, were retrospectively analyzed, including demographics, injury factors, length of cancer incubation period, lesion location, ulcer area, pathological type, bone invasion, lymph node metastasis, surgical methods, repair methods and prognosis. Results: There were 70 males and 19 females among 89 patients with lower limbs Marjolin’s ulcers. The most common injuries were flame burn (42 cases), trauma (19 cases), and burns (12 cases). The lesions were most common in the lower leg (31 cases), followed by the thigh (11 cases) and the heel (11 cases). The ulcer area was 1.5–600.0 cm2. There were 80 cases of squamous cell carcinoma, 8 cases of verrucous carcinoma, and 1 case of sarcoma. Before operation, 78 cases of inguinal lymphadenectasis were found, 49 cases of inguinal lymph node dissection, 29 cases of simple lymph node biopsy and resection, and 9 cases of lymph node metastasis and 8 cases of bone invasion were observed; 24 cases of amputation, 53 cases of extended resection and skin grafts, and 12 patients of extensive resection and flap transplantation were performed. Sixty-five cases were followed up, and 8 cases recurred, including 2 cases of amputation patients and 6 cases of extended resection patients. There was no relationship between recurrence of tumors and surgical methods (P>0.05). Conclusion: The recurrence and metastasis rate of Marjolin’s ulcers in lower limbs is high, requiring early detection, early diagnosis, early surgical treatment and regular follow-up. Lnguinal lymphadenectasis is more common and requires lymph node biopsy and lymphadenectomy, or lymph node dissection. Extended local resection, skin graft or flap repair is the main treatment methods. However, amputation can be considered if the cancer is big, the invasion is deep, and the lower extremity scar is extensive and combined with severe deformity.
2019 Vol. 44 (2): 180-185 [Abstract] ( 41 ) [HTML 1KB] [PDF 730KB] ( 75 )
186 LI Yali1, NING Wenya1, TAN Liwen2, ZHANG Chunyan2, DENG Yunlong1
Psychological characteristics in different clinical subgroups of insomniacs
Objective: To investigate psychological characteristics in diff erent clinical subgroups of insomniacs, and to provide the basis for the accurate simplifi cation of cognitive behavioral therapy for insomnia. Methods: A total of 212 insomniacs from November 2014 to June 2017 in Clinical Psychology Department or Sleep Department of 2 general hospitals in Hunan Province were included in convenient and classifi ed into sleep onset insomnia (SOI), diffi culty maintaining insomnia (DMI), early morning awakening insomnia (EMAI), and combined insomnia (CI) subgroups. Ford Insomnia Response to Stress Test (FIRST), Simplified Coping Style Questionnaire (SCSQ), Dysfunctional Beliefs and Attitudes about Sleep Scale 16 version (DBAS-16), Sleep-Related Behavior Questionnaire (SRBQ), Pre-sleep Arousal Scale (PSAS), Center for Epidemiological Studies Depression Scale (CES-D), Beck Anxiety Inventory (BAI) were used to investigate the psychological characteristics. Results: SOI and CI insomniacs had a higher frequency in use of sleep-related behavior than those with DMI; CI had a higher frequency in use of sleep-related behavior than those with EMAI (all P<0.05). Both SOI and CI insomniacs had a higher level of pre-sleep cognitive arousal than DMI and EMAI (all P<0.05). CI insomniacs noticed more consequences of insomnia and had more worries on insomnia than DMI, and CI insomniacs had more expectations of sleep than SOI (all P<0.05). Conclusion: Insomniacs with different clinical subgroups have different features of psychological characteristics. Both the insomnia subgroups and the psychological characteristics should be taken into account when we simplify cognitive behavioral therapy for insomnia (CBT-I) precisely.
2019 Vol. 44 (2): 186-192 [Abstract] ( 36 ) [HTML 1KB] [PDF 369KB] ( 73 )
193 WEI Xiang, NING Peishan, CHENG Xunjie, HU Guoqing (
Disease burden among people aged 70 years or older in countries with different developmental levels from 1990 to 2016
2019 Vol. 44 (2): 193-200 [Abstract] ( 33 ) [HTML 1KB] [PDF 528KB] ( 65 )
201 JI Xiaolin1, WANG Kangkai2, WANG Nian2
Research advance in chondrogenic differentiation of adipose-derived stem cells
Articular cartilage lesions due to injury or other pathology are often difficult to heal, and the outcomes of the clinical treatment widely used today are far from satisfaction. Adipose-derived stem cells (ADSCs) are multipotent stem cells from adipose tissue. Tissue engineering based on the ability of ADSCs to differentiate into chondrocytes provides a new idea for the repair and regeneration of articular cartilage defects. Th e method for inducing the diff erentiation of ADSCs into chondrocytes in vitro who have been quite well established, which mainly include the use of growth factors and scaffolds to mimic the in vivo microenvironment, thereby promoting the diff erentiation of ADSCs into chondrocytes.
2019 Vol. 44 (2): 201-208 [Abstract] ( 40 ) [HTML 1KB] [PDF 380KB] ( 100 )
209 GU Baohong1, LI Xuemei1, HU Jike1, ZHANG Fan1, LU Juanjuan2, CHEN Hao2
Preventive strategy for post-ERCP pancreatitis
Endoscopic retrograde cholangiopancreatography (ERCP) is an irreplaceable measure with minimally invasive diagnosis and treatment of endoscopy for biliary and pancreatic diseases, but the related complications associated with ERCP are the highest among the endoscopic procedures. Post-ERCP pancreatitis (PEP) is one of the most common complications with life-threatening in severe cases. Early active prevention can eff ectively reduce the incidence of post-ERCP pancreatitis. At present, measures including preoperative rectal non-steroidal anti-inflammatory drugs and prophylactic pancreatic stent placement, have definite effective strategy in clinic. Aggressive hydration with lactated Ringer’s solution is also a safe and eff ective way to prevent PEP.
2019 Vol. 44 (2): 209-215 [Abstract] ( 38 ) [HTML 1KB] [PDF 360KB] ( 75 )
216 ZENG Xiaohui, XU Peipei, WANG Yunhua
Health economics analysis for 18F-fluorodeoxyglucose positron-emission tomography compared with computed tomography in lung cancer
Compared with conventional imaging, 18F-fluorodeoxyglucose positron-emission tomography compared with computed tomography (18F-FDG PET/CT) possesses higher sensitivity and specificity in the diagnosis of solitary pulmonary nodule (SPN) and lung cancer. From the perspective of health economics, PET/CT is more suitable strategy for diagnose of SPN with intermediate probability of malignancy, and has good health economics value in preoperative staging diagnosis and follow-up aft er radiotherapy and chemotherapy of lung cancer. Th e evaluation method, eff ect index and comparison method used in the health economics research of PET/CT for lung cancer diagnosis and treatment are cost-eff ect analysis, life year and incremental cost-eff ect ratio, respectively. Case tracking and follow-up was a means of early studies on PET/CT health economics, and in recent years mathematical models are used in most studies.
2019 Vol. 44 (2): 216-221 [Abstract] ( 35 ) [HTML 1KB] [PDF 305KB] ( 69 )
222 LIN Changsong, GUO Zi, MO Zhaohui
Nivolumab-induced hypothyroidism: A case report
Nivolumab is an anti-programmed cell death (anti-PD-1) monoclonal antibody, which is a new drug for tumor immunotherapy. A 73-year-old female patient with colorectal cancer 3 years aft er surgery was treated in the Endocrinology Department of Th ird Xiangya Hospital, Central South University, who developed severe hypothyroidism resulting from treatment with nivolumab. Aft er 4 months treatment of nivolumab, this patient presented with symptoms such as fatigue, dizziness, jaundice and palpebral edema, with decreased levels of FT3 and FT4 and elevated levels of TSH. Subsequently, nivolumab treatment was terminated. This patient’s symptoms were relieved and thyroid function returned to normal aft er thyroxine replacement therapy. Th e clinical diagnosis was considered to be nivolumab-induced autoimmune thyroid damage, which was an immune-related adverse reaction in the treatment.
2019 Vol. 44 (2): 222-224 [Abstract] ( 42 ) [HTML 1KB] [PDF 259KB] ( 68 )
20192
2019 Vol. 44 (2): 20192-20192 [Abstract] ( 26 ) [HTML 1KB] [PDF 824KB] ( 74 )
Copyright © 2009 Editorial Office of Journal of Central South University (Medical Sciences)