Abstract Systemic sclerosis (SSc) is an autoimmune disease with unknown etiology, characterized by
vasculopathy, infl ammation, and extensive fi brosis in the skin and organs. Fibrosis is the hallmark of
SSc and contributes to its high mortality. In recent years, with the in-depth study of the epigenetics
of SSc (DNA methylation, histone modifi cation, and non-coding RNA), the DNA methylation and
miRNA has been the most widely studied. Abnormal DNA methylation can infl uence the function
of vascular endothelial cells, CD4+ T cells, and fibroblasts in SSc. MiRNAs in serum is closely
related to autoantibodies, SSc disease activity and complications, and miRNAs in fi broblasts can
directly aff ect the activation of fi broblasts.
Fund:This work was supported by the National
Natural Science Foundation (81671622, 81771765) and the Natural Science Foundation of Hunan Province (2018JJ3823), China.