Abstract：Calcific uremic arteriopathy (CUA), termed calciphylaxis, is a rare but highly fatal clinical
syndrome. There is no clearly laboratory diagnostic criteria for CUA. The medium and small
arterial calcification and microthrombosis discovered by skin biopsy, radiologic imaging，bone
scan and the evidence of activation of the bone morphogenetic protein signal (BMPs) transduction
pathway are useful for early diagnosis of this disease. Th e common therapies (including intravenous
sodium thiosulfate (STS) and bisphosphonates, hyperbaric oxygen therapy and other symptomatic
supports) are used for the management of wounds, pain, nutrition, dialysis and so on. Controlling
the chronic kidney disease-mineral and bone disorder (CKD-MBD) and some complications
of dialysis and drugs (such as warfarin, active vitamin D) can prevent CUA. However, CUA
patients still have poor prognosis and high mortality. Since some patients progress rapidly, it is of great importance to make early diagnosis and provide effective treatments with multidisciplinary
周月异，张浩，孙剑，季迎，刘纪实. 钙性尿毒症性小动脉病的早期诊断及防治进展[J]. 中南大学学报(医学版), 2018, 43(11): 1251-1256.
ZHOU Yueyi, ZHANG Hao, SUN Jian, JI Ying, LIU Jishi. Early diagnosis, prevention and treatment for calcific uremic arteriolopathy. Journal of Central South University(Medical Scienc, 2018, 43(11): 1251-1256.