Role of NMDA receptor-mediated abnormalities of GABAergic interneurons in psychiatric disorders
1. Department of Anesthesiology, Zhongda Hospital, Southeast University, Nanjing 210009; 2. Department of Anesthesiology and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University,
Zhengzhou 450052, China
Abstract：GABAergic interneurons are neurons that mainly release the neurotransmitter of γ -
aminobutyric acid (GABA), accounting for approximately 20% of the total number of
neurons in the cerebral cortex. They form wide synaptic connections with the pyramidal
cells and regulate the pyramidal activity, playing an important role in maintenance of
excitation/inhibition balance in cortical circuits. Recently, studies have shown that
GABAergic interneurons dysfunction is the key mechanism underlying neuropsychiatric
disorders such as schizophrenia, depression, and autism. N-methyl-D-aspartic acid (NMDA)
receptors are the main receptors in GABAergic interneurons, and its dysfunction and different subunit deletions can mediate GABAergic interneuron dysfunction.
李墅明，张广芬，杨建军. NMDA受体介导的GABA能中间神经元异常在精神疾病中的作用[J]. 中南大学学报(医学版), 2020, 45(2): 176-180.
LI Shuming, ZHANG Guangfen, YANG Jianjun. Role of NMDA receptor-mediated abnormalities of GABAergic interneurons in psychiatric disorders. Journal of Central South University(Medical Scienc, 2020, 45(2): 176-180.
